i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
#semaglutide 2026-02-01
Sunday50 messages13 participantstimes are UTC
Highlights from this day
- net_peptide — the long half life flattens the trough more than people expect, i never felt a day seven dip, i could be wrong 19:16
- net_peptide — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 19:23
- protein_floor — did anybody find a difference between MKM and pharmacy at the same 5 19:34
- VialBot — Assay note: Homopeptide lot G-0641 reported at 96.8% of label content. 19:37
- hair_month_four — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 22:48
slower worked better
im at 1 and stuck, did anyone break a plateau without going up
the plateau hit me at 5 weeks and moved again about a month later without a dose change
[edited]vials not pens here
thats STEP 1
2.4 is the ceiling
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
held there too
same dose day
👀3❤️1
the long half life flattens the trough more than people expect, i never felt a day seven dip, i could be wrong
🙏15
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
🎉17👍11😂17
did anyone hold at 15 longer than four weeks before going up
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
dose day is sunday for me only because thats when i remember, not because sunday matters
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
did anybody find a difference between MKM and pharmacy at the same 5
SELECT wasnt weight
chromatogram-overlay.png
1240 × 720 · 767 KB · not retained in the public archive
Assay note: Homopeptide lot G-0641 reported at 96.8% of label content.
🤝1⚠️5
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, someone check my working
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
vial units and pen clicks are different systems, mixing the two is how people end up wrong
*Medutest not the other one
steady state takes weeks
did the STEP 4 withdrawal arm show what i think it showed
my 40 vial in 1.5ml gives 2mg/ml so 10 lands on 10 units, thats why i picked that volume
what did SELECT actually measure, i see it quoted for everything
give it four weeks
i held at 2.5 for 9 months and it was the best decision i made
five week steps worked better for me than four, purely on how the second week felt
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
how long did the first 17kg take for people at the low doses
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
anyone compared their 10 vial dosing against the pen increments
🧪1📈3
not the same trial
ok so licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
seven days ish
[edited]mine faded too
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, happy to be corrected
quick one 19 months at 2.4 and the honest summary is diminishing returns after the first half
my dose day drifted from friday to sunday, does that reset anything
genuine question how many weeks before you noticed anything at 0.25
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
[edited]moving my dose day by a day or two never did anything noticeable for me
went too fast once
🔥9
follow up my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, thats just me
€185 a month for compounded against what brand costs locally is why most people here use vials
did anyone titrate slower than four weeks a step and how did that go
does anyone actually run a five week step instead of four
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
❤️14👍4
STEP is several trials, so saying STEP said x is usually wrong without a number after it, not advice obviously
[edited]