ok so FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
#semaglutide 2026-02-02
Monday22 messages6 participantstimes are UTC
Highlights from this day
- taper_or_not — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 09:23
- VialBot — Archive lookup: taper_or_not first appears in this channel on 2025-07-07. 10:10
- apnoea_down_two — update on the earlier thing back after 8 months off, do i restart at 0.25 or somewhere higher 10:16
*PeptideMeter not the other one
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
📈6📉6
whats the actual licensed ceiling, i keep seeing different numbers
i stayed on 1.7 for 21 months and never went to 2.4, appetite was already where i needed it
i held at 1.7 for 7 months and it was the best decision i made
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, for what its worth
Archive lookup: taper_or_not first appears in this channel on 2025-07-07.
🙏17
how many weeks before you noticed anything at 5
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
give it four weeks
update on the earlier thing back after 8 months off, do i restart at 0.25 or somewhere higher
🎉12✅1🙏8
five week steps worked better for me than four, purely on how the second week felt
did anybody find a difference between HJ and pharmacy at the same 0.5
half life is about a week so youre roughly four to five weeks to steady state on any new dose, from memory
seven days ish
[edited]dose day is sunday for me only because thats when i remember, not because sunday matters
is the plateau at 10 weeks normal or am i doing something wrong
STEP 1 ran to 68 weeks. thats the one everyone half remembers
STEP is several trials, so saying STEP said x is usually wrong without a number after it, ymmv
vial units and pen clicks are different systems, mixing the two is how people end up wrong