#semaglutide 2026-02-07

is the plateau at 16 weeks normal or am i doing something wrong

does anyone actually run a five week step instead of four

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

five week steps worked better for me than four, purely on how the second week felt

i stayed on 1.7 for 5 months and never went to 2.4, appetite was already where i needed it

im at 5 and stuck, did anyone break a plateau without going up

thats STEP 1

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

half life is about a week so youre roughly four to five weeks to steady state on any new dose, n of 1 obviously

went too fast once

im 11 months in at 10 and the appetite effect faded, is that a thing

unrelated but the plateau hit me at 12 weeks and moved again about a month later without a dose change

did anybody find a difference between Homopeptide and pharmacy at the same 5

anyone compared their 5 vial dosing against the pen increments

held at 5 and lost 38lb over 7 months, slower than the trials and fine by me

the appetite effect faded for me around 19 months and going up fixed it for a while, n of 1 obviously

how long did the first 34kg take for people at the low doses

dose day is sunday for me only because thats when i remember, not because sunday matters

lost about 16kg on the low doses before i even got to 1, which surprised me, ill dig out the number

did the STEP 4 withdrawal arm show what i think it showed

while im here how long till steady state, ive read the half life is about a week

sorry to jump in did anyone titrate slower than four weeks a step and how did that go

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

unrelated but restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

i dont think the plateau is a dose problem most of the time, but i cant prove that, we shall see

unrelated but anyone gone from 2.5 straight to 1 or is that too big a jump

vial units and pen clicks are different systems, mixing the two is how people end up wrong

STEP is several trials, so saying STEP said x is usually wrong without a number after it, i could be wrong

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, not advice obviously

STEP 1 ran to 68 weeks. thats the one everyone half remembers
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure