if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, we shall see
#semaglutide 2026-02-17
Tuesday55 messages12 participantstimes are UTC
Highlights from this day
- juno_joins — 9 months at 2.4 and the honest summary is diminishing returns after the first half 18:47
- juno_joins — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ill dig out the number 19:02
- pinch_not_stretch — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 20:58
- septum_sal — i dont think the plateau is a dose problem most of the time, but i cant prove that 20:59
- pinch_not_stretch — €38 a month for compounded against what brand costs locally is why most people here use vials, anyway 21:18
compounded and brand felt the same to me at 10, which is one person and nothing more
seven days ish
the plateau hit me at 29 weeks and moved again about a month later without a dose change
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
restarted after 26 months off at a low dose and the nausea arrived exactly like the first time
[edited]vial units and pen clicks are different systems, mixing the two is how people end up wrong
does the seven day half life mean the last two days are weaker
9 months at 2.4 and the honest summary is diminishing returns after the first half
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgsteady state is the bit people skip, judging a new dose after eight days tells you almost nothing
steady state takes weeks
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ill dig out the number
❤️9🔥2
went too fast once
i held at 15 for 3 months and it was the best decision i made
10 months at 2.4 and the honest summary is diminishing returns after the first half
whats the actual licensed ceiling, i keep seeing different numbers
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
plateaus move
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same dose day
unrelated but changed my mind on the four week rule, i think it depends entirely on how the current dose feels
mine faded too
did anybody find a difference between Homopeptide and pharmacy at the same 2.5
give it four weeks
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, for what its worth
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
lost about 36kg on the low doses before i even got to 1, which surprised me
thats STEP 1
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, ymmv
update on the earlier thing held at 0.5 and lost 86lb over 25 months, slower than the trials and fine by me
vials not pens here
is there a reason to hold at 1.7 rather than going to 2.4
back after 4 months off, do i restart at 0.25 or somewhere higher
2.4 is the ceiling
dose day is sunday for me only because thats when i remember, not because sunday matters, i have it written down somewhere
five week steps worked better for me than four, purely on how the second week felt
moving my dose day by a day or two never did anything noticeable for me
half life is about a week so youre roughly four to five weeks to steady state on any new dose, someone check my working
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
the long half life flattens the trough more than people expect, i never felt a day seven dip, your mileage will differ
genuine question the appetite effect faded for me around 12 months and going up fixed it for a while
SELECT wasnt weight
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
my PeptideMeter report on the GL Biochem vial came back 99.4 against a certificate saying 97.4
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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i dont think the plateau is a dose problem most of the time, but i cant prove that
🙏1📈10
€38 a month for compounded against what brand costs locally is why most people here use vials, anyway
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Batch lookup B-0329: 9 independent reports on file, earliest 2025-08-23.
my 20 vial in 3ml gives 2.5mg/ml so 0.25 lands on 10 units, thats why i picked that volume, take that with a pinch of salt
pinch_not_stretchmy PeptideMeter report on the GL Biochem vial came back 99.4 against a certificate…
STEP 1 ran to 68 weeks. thats the one everyone half remembers
vials not pens here
STEP is several trials, so saying STEP said x is usually wrong without a number after it
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
did anyone titrate slower than four weeks a step and how did that go
mine faded too
anyone gone from 1 straight to 7.5 or is that too big a jump