vialroom

#semaglutide 2026-02-21

Saturday32 messages10 participantstimes are UTC
Highlights from this day
  • nordic_price_nils — ok so my Medutest report on the TFC vial came back 99.2 against a certificate saying 98.1, thats one data point 12:55
  • cat_on_the_tray — anyone gone from 1.7 straight to 2.4 or is that too big a jump 13:09
  • nordic_price_nils — unrelated but does moving my dose day by two days matter with a seven day half life 13:21
  • seven_five_sweet — held at 2.4 and lost 40lb over 25 months, slower than the trials and fine by me 13:51
  • VialBot — Batch lookup F-1330: 9 independent reports on file, earliest 2025-08-20. 15:55
AA

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

SS

26 months at 2.4 and the honest summary is diminishing returns after the first half, happy to be corrected

📉4

same dose day

HS

i dont think the plateau is a dose problem most of the time, but i cant prove that

NP

ok so my Medutest report on the TFC vial came back 99.2 against a certificate saying 98.1, thats one data point

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, i think

CO

anyone gone from 1.7 straight to 2.4 or is that too big a jump

⚠️4❤️3🙏7
NP

unrelated but does moving my dose day by two days matter with a seven day half life

🔥13
SF

held at 2.4 and lost 40lb over 25 months, slower than the trials and fine by me

💀15

2.4 is the ceiling

im at 2 and stuck, did anyone break a plateau without going up

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

SS

half life is about a week so youre roughly four to five weeks to steady state on any new dose

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

SS

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

SF

compounded and brand felt the same to me at 15, which is one person and nothing more
my 5 vial in 3ml gives 5mg/ml so 2.5 lands on 20 units, thats why i picked that volume

[edited]
👀1

plateaus move

does anyone actually run a five week step instead of four

slower worked better

📉3👍1

thats STEP 1

VB

Batch lookup F-1330: 9 independent reports on file, earliest 2025-08-20.

SF

vials not pens here

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes (STEP 2)
The Lancet · 2021
The type 2 diabetes population, where the weight response is generally smaller.
GA

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

SF

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, still working it out

give it four weeks

coming back to this five week steps worked better for me than four, purely on how the second week felt, ask me again in a month