how did people handle the jump from 1 to 1.7
#semaglutide 2026-02-22
Sunday65 messages14 participantstimes are UTC
Highlights from this day
- food_noise_off — the appetite effect faded for me around 14 months and going up fixed it for a while 19:55
- food_noise_off — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 21:11
- verify_or_dont — ok so anyone compared their 5 vial dosing against the pen increments 21:37
thats STEP 1
vials not pens here
🤝13
is 2.4 the top or do people go past it
went too fast once
i dont think the plateau is a dose problem most of the time, but i cant prove that
slower worked better
Reminder set. I will post here in 4 days.
🧊11
whats the actual licensed ceiling, i keep seeing different numbers
2.4 is the ceiling
📈1🧊2
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
£38 a month for compounded against what brand costs locally is why most people here use vials
the plateau hit me at 4 weeks and moved again about a month later without a dose change
❤️1
back after 16 months off, do i restart at 0.25 or somewhere higher
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
is the plateau at 30 weeks normal or am i doing something wrong
steady state takes weeks
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
ok so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
vial units and pen clicks are different systems, mixing the two is how people end up wrong
🎉10👍3🤝4
the long half life flattens the trough more than people expect, i never felt a day seven dip
give it four weeks
is the plateau usually appetite coming back or just the scale stopping
Verification log updated: QST — evidence added, status unchanged.
📈1❤️1
the appetite effect faded for me around 14 months and going up fixed it for a while
✅7🧪13
how long did the first 8kg take for people at the low doses
Reminder set. I will post here in 6 days.
STEP is several trials, so saying STEP said x is usually wrong without a number after it
[edited]seven days ish
my 10 vial in 0.5ml gives 4mg/ml so 12 lands on 10 units, thats why i picked that volume
ok so how long till steady state, ive read the half life is about a week
quick one did anyone titrate slower than four weeks a step and how did that go
anyone gone from 10 straight to 0.25 or is that too big a jump
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
[edited]SELECT wasnt weight
does anyone actually run a five week step instead of four
plateaus move
half life is about a week so youre roughly four to five weeks to steady state on any new dose
slightly off topic but dose day is sunday for me only because thats when i remember, not because sunday matters
quick one if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
5 months at 2.4 and the honest summary is diminishing returns after the first half
held there too
quick one moving my dose day by a day or two never did anything noticeable for me, your mileage will differ
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
✅8❤️7🙏2
sorry to jump in went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
mine faded too
[edited]how many weeks before you noticed anything at 0.5
ok so anyone compared their 5 vial dosing against the pen increments
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg👀6💀15🎉11
my dose day drifted from friday to sunday, does that reset anything
does the licensed ceiling for weight differ from the diabetes one
brand vs compounded, is there a difference people can actually feel
lost about 28kg on the low doses before i even got to 1, which surprised me
does moving my dose day by two days matter with a seven day half life
STEP 1 ran to 68 weeks. thats the one everyone half remembers, take that with a pinch of salt
💀4
compounded and brand felt the same to me at 0.25, which is one person and nothing more
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdid anyone hold at 0.5 longer than four weeks before going up
💀15👀1
for the archive i held at 0.5 for 7 months and it was the best decision i made
👀1🧊13
ok so is there a reason to hold at 1.7 rather than going to 2.4
Recon calculator: 30mg in 1ml = 4mg/ml.
compounded and brand felt the same to me at 1.7, which is one person and nothing more
did anybody find a difference between WXT and pharmacy at the same 1
coming back to this i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
my PeptideMeter report on the TFC vial came back 99 against a certificate saying 99.4