how long till steady state, ive read the half life is about a week
i held at 10 for 3 months and it was the best decision i made
#semaglutide 2026-02-23
Monday48 messages12 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working 17:55
- holly_holds — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 19:21
- coa_or_cope — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 19:52
- halifax_hplc — five week steps worked better for me than four, purely on how the second week felt 20:18
did anyone titrate slower than four weeks a step and how did that go
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how long did the first 13kg take for people at the low doses
the appetite effect faded for me around 5 months and going up fixed it for a while
compounded and brand felt the same to me at 12, which is one person and nothing more
STEP 1 ran to 68 weeks. thats the one everyone half remembers, happy to be corrected
did anybody find a difference between CPC and pharmacy at the same 2.4
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
does the licensed ceiling for weight differ from the diabetes one
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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im 21 months in at 0.5 and the appetite effect faded, is that a thing
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is the plateau usually appetite coming back or just the scale stopping
ok so is 2.4 the top or do people go past it
is there a reason to hold at 1.7 rather than going to 2.4
my dose day drifted from friday to sunday, does that reset anything
restarted after 20 months off at a low dose and the nausea arrived exactly like the first time
STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working
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the long half life flattens the trough more than people expect, i never felt a day seven dip
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not the same trial
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lost about 39kg on the low doses before i even got to 1, which surprised me
i dont think the plateau is a dose problem most of the time, but i cant prove that, thats one data point
how many weeks before you noticed anything at 0.5
plateaus move
slightly off topic but 25 months at 2.4 and the honest summary is diminishing returns after the first half
what did SELECT actually measure, i see it quoted for everything
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, i have it written down somewhere
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held at 12 and lost 96lb over 4 months, slower than the trials and fine by me
my 15 vial in 1ml gives 2mg/ml so 7.5 lands on 30 units, thats why i picked that volume
i held at 12 for 2 months and it was the best decision i made
Batch lookup E-2205: 6 independent reports on file, earliest 2025-07-18.
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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how did people handle the jump from 1 to 1.7
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
does moving my dose day by two days matter with a seven day half life
five week steps worked better for me than four, purely on how the second week felt
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it, still working it out
STEP is several trials, so saying STEP said x is usually wrong without a number after it
does anyone actually run a five week step instead of four
dose day is sunday for me only because thats when i remember, not because sunday matters
same dose day
thats STEP 1
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*that should say weekly
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
brand vs compounded, is there a difference people can actually feel
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anyone gone from 2 straight to 2.5 or is that too big a jump
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