the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
#semaglutide 2026-02-28
Saturday48 messages12 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — SGN, lot C-4402, purity 99% (Medutest). 20:30
- two_four_ceiling — my Janoshik report on the QYB vial came back 97.4 against a certificate saying 99.2 20:38
- VialBot — Archive lookup: two_four_ceiling first appears in this channel on 2025-07-14. 20:48
- split_shipment — the plateau hit me at 15 weeks and moved again about a month later without a dose change 21:10
- slow.taper — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 23:17
New independent result logged — SGN, lot C-4402, purity 99% (Medutest).
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does the seven day half life mean the last two days are weaker
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my Janoshik report on the QYB vial came back 97.4 against a certificate saying 99.2
held at 2.5 and lost 68lb over 4 months, slower than the trials and fine by me
$55 a month for compounded against what brand costs locally is why most people here use vials, i think
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give it four weeks
Archive lookup: two_four_ceiling first appears in this channel on 2025-07-14.
coming back to this went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
STEP 1 ran to 68 weeks. thats the one everyone half remembers
i dont think the plateau is a dose problem most of the time, but i cant prove that
[edited]whats the actual licensed ceiling, i keep seeing different numbers
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is the plateau usually appetite coming back or just the scale stopping
did anybody find a difference between SSA and pharmacy at the same 15
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does the licensed ceiling for weight differ from the diabetes one
the plateau hit me at 15 weeks and moved again about a month later without a dose change
steady state takes weeks
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
back after 25 months off, do i restart at 0.25 or somewhere higher
im 6 months in at 2 and the appetite effect faded, is that a thing
is there a reason to hold at 1.7 rather than going to 2.4
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held there too
vials not pens here
lost about 26kg on the low doses before i even got to 1, which surprised me
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
mine faded too
thats STEP 1
my 40 vial in 2ml gives 8mg/ml so 0.5 lands on 8 units, thats why i picked that volume
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
2.4 is the ceiling
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same dose day
the long half life flattens the trough more than people expect, i never felt a day seven dip, i think
seven days ish
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anyone gone from 15 straight to 10 or is that too big a jump
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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did anyone hold at 5 longer than four weeks before going up
SELECT wasnt weight
update on the earlier thing i held at 1 for 2 months and it was the best decision i made, still working it out
does anyone actually run a five week step instead of four
plateaus move
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went too fast once
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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does moving my dose day by two days matter with a seven day half life
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not the same trial
[edited]