steady state takes weeks
#semaglutide 2026-03-01
Sunday67 messages12 participantstimes are UTC
Highlights from this day
- taper_tess — restarted after 4 months off at a low dose and the nausea arrived exactly like the first time 21:56
- cat_on_the_tray — 26 months at 2.4 and the honest summary is diminishing returns after the first half 22:29
- no_escrow_nate — sorry to jump in brand vs compounded, is there a difference people can actually feel the trials titrated on a fixed schedule, most people here dont, worth remembering… 22:47
- surpass_two — whats the actual licensed ceiling, i keep seeing different numbers 22:49
- surpass_two — held at 2 and lost 56lb over 9 months, slower than the trials and fine by me 22:52
my VendorInvestigate report on the FGP vial came back 99.2 against a certificate saying 98.6
vial units and pen clicks are different systems, mixing the two is how people end up wrong
does anyone actually run a five week step instead of four
ok so licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, we shall see
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
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unrelated but went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ask me again in a month
2.4 is the ceiling
slightly off topic but the plateau hit me at 16 weeks and moved again about a month later without a dose change
restarted after 4 months off at a low dose and the nausea arrived exactly like the first time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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*VendorInvestigate not the other one
i dont think the plateau is a dose problem most of the time, but i cant prove that, i have it written down somewhere
lost about 48kg on the low doses before i even got to 1, which surprised me, i think
vials not pens here
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i held at 2 for 9 months and it was the best decision i made
right so im at 1.7 and stuck, did anyone break a plateau without going up
how many weeks before you noticed anything at 2
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming back to this i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
how did people handle the jump from 1 to 1.7
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is there a reason to hold at 1.7 rather than going to 2.4
my 15 vial in 1.5ml gives 10mg/ml so 2.4 lands on 50 units, thats why i picked that volume
dose day is sunday for me only because thats when i remember, not because sunday matters
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
held there too
the long half life flattens the trough more than people expect, i never felt a day seven dip
*Janoshik not the other one
same dose day
26 months at 2.4 and the honest summary is diminishing returns after the first half
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
five week steps worked better for me than four, purely on how the second week felt, your mileage will differ
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did anyone hold at 0.25 longer than four weeks before going up
half life is about a week so youre roughly four to five weeks to steady state on any new dose
slower worked better
the appetite effect faded for me around 21 months and going up fixed it for a while, from memory
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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$120 a month for compounded against what brand costs locally is why most people here use vials, ymmv
thats STEP 1
sorry to jump in brand vs compounded, is there a difference people can actually feel
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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whats the actual licensed ceiling, i keep seeing different numbers
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held at 2 and lost 56lb over 9 months, slower than the trials and fine by me
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went too fast once
moving my dose day by a day or two never did anything noticeable for me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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plateaus move
went too fast once
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
give it four weeks
seven days ish
SELECT wasnt weight
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while im here SELECT wasnt weight
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP is several trials, so saying STEP said x is usually wrong without a number after it
thats STEP 1
went too fast once
how long till steady state, ive read the half life is about a week
was FLOW the one that ran to 68 weeks or am i mixing them up
im 17 months in at 1 and the appetite effect faded, is that a thing
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2.4 is the ceiling
plateaus move
what did SELECT actually measure, i see it quoted for everything
went too fast once
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compounded and brand felt the same to me at 2, which is one person and nothing more