does anyone actually run a five week step instead of four
#semaglutide 2026-03-04
Wednesday47 messages11 participantstimes are UTC
Highlights from this day
- bram_begins — did anyone titrate slower than four weeks a step and how did that go 20:44
- bram_begins — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 20:53
- mood_dip_mari — does moving my dose day by two days matter with a seven day half life 21:23
- seven_five_sweet — anyone compared their 2.5 vial dosing against the pen increments 22:58
- seven_five_sweet — moving my dose day by a day or two never did anything noticeable for me, someone check my working STEP 4 had the withdrawal arm, thats the one people quote when they… 23:17
2.4 is the ceiling
did anyone titrate slower than four weeks a step and how did that go
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
im at 5 and stuck, did anyone break a plateau without going up
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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£185 a month for compounded against what brand costs locally is why most people here use vials
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i held at 2 for 3 months and it was the best decision i made
give it four weeks
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compounded and brand felt the same to me at 2.5, which is one person and nothing more
slower worked better
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgmy dose day drifted from friday to sunday, does that reset anything
i dont think the plateau is a dose problem most of the time, but i cant prove that
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
does moving my dose day by two days matter with a seven day half life
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is the plateau usually appetite coming back or just the scale stopping
unrelated but SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
same dose day
peptidemeter-summary-e-2205.pdf
2 pages · 411 KB · not retained in the public archive
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did the STEP 4 withdrawal arm show what i think it showed
five week steps worked better for me than four, purely on how the second week felt, someone check my working
lost about 47kg on the low doses before i even got to 1, which surprised me
thats STEP 1
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coming back to this back after 24 months off, do i restart at 0.25 or somewhere higher
peptidemeter-summary-b-0329.pdf
2 pages · 239 KB · not retained in the public archive
how long did the first 38kg take for people at the low doses
held there too
what did SELECT actually measure, i see it quoted for everything
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, we shall see
*VendorInvestigate not the other one
coming back to this if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
does the licensed ceiling for weight differ from the diabetes one
unrelated but STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, i think
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
went too fast once
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, thats one data point
unrelated but held at 1 and lost 11lb over 5 months, slower than the trials and fine by me
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
steady state takes weeks
vials not pens here
did anyone hold at 1 longer than four weeks before going up
anyone compared their 2.5 vial dosing against the pen increments
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe appetite effect faded for me around 24 months and going up fixed it for a while
did anybody find a difference between ERP and pharmacy at the same 1.7
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
moving my dose day by a day or two never did anything noticeable for me, someone check my working
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
plateaus move
the plateau hit me at 18 weeks and moved again about a month later without a dose change
my 10 vial in 3ml gives 2mg/ml so 12 lands on 40 units, thats why i picked that volume