slower worked better
#semaglutide 2026-03-06
Friday33 messages7 participantstimes are UTC
Highlights from this day
- transit_degrade — was STEP 4 the one that ran to 68 weeks or am i mixing them up 09:21
- seizure_letter — the appetite effect faded for me around 16 months and going up fixed it for a while 09:59
- net_peptide — is the plateau usually appetite coming back or just the scale stopping 14:45
- net_peptide — how long till steady state, ive read the half life is about a week 15:17
not the same trial
the plateau hit me at 25 weeks and moved again about a month later without a dose change
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
was STEP 4 the one that ran to 68 weeks or am i mixing them up
did anyone hold at 0.5 longer than four weeks before going up
restarted after 4 months off at a low dose and the nausea arrived exactly like the first time
STEP is several trials, so saying STEP said x is usually wrong without a number after it
compounded and brand felt the same to me at 2.4, which is one person and nothing more
how did people handle the jump from 1 to 1.7
*Janoshik not the other one
mine faded too
plateaus move
vial units and pen clicks are different systems, mixing the two is how people end up wrong
the appetite effect faded for me around 16 months and going up fixed it for a while
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
is there a reason to hold at 1.7 rather than going to 2.4
did the STEP 4 withdrawal arm show what i think it showed
factory_direct_fiSTEP is several trials, so saying STEP said x is usually wrong without a number after it
five week steps worked better for me than four, purely on how the second week felt
does the seven day half life mean the last two days are weaker
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
whats the actual licensed ceiling, i keep seeing different numbers
1 months at 2.4 and the honest summary is diminishing returns after the first half
half life is about a week so youre roughly four to five weeks to steady state on any new dose
held at 1.7 and lost 94lb over 21 months, slower than the trials and fine by me
half life is about a week so youre roughly four to five weeks to steady state on any new dose, i think
is the plateau usually appetite coming back or just the scale stopping
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held there too
went too fast once
slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
how long till steady state, ive read the half life is about a week
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right so is 2.4 the top or do people go past it
sorry to jump in i dont think the plateau is a dose problem most of the time, but i cant prove that
follow up i stayed on 1.7 for 1 months and never went to 2.4, appetite was already where i needed it
STEP 1 ran to 68 weeks. thats the one everyone half remembers