went too fast once
#semaglutide 2026-03-26
Thursday56 messages13 participantstimes are UTC
Highlights from this day
- nhs_pathway_nell — did anyone hold at 12 longer than four weeks before going up 17:16
- tail_factor — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 18:42
- tail_factor — £240 a month for compounded against what brand costs locally is why most people here use vials 19:06
- taper_or_not — the plateau hit me at 26 weeks and moved again about a month later without a dose change 21:30
slower worked better
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does anyone actually run a five week step instead of four
quick one restarted after 5 months off at a low dose and the nausea arrived exactly like the first time
SELECT wasnt weight
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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did anyone hold at 12 longer than four weeks before going up
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plateaus move
[edited]whats the actual licensed ceiling, i keep seeing different numbers
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
moving my dose day by a day or two never did anything noticeable for me
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
back after 25 months off, do i restart at 0.25 or somewhere higher
anyone gone from 0.25 straight to 2.5 or is that too big a jump
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vials not pens here
fridge-temps.csv
308 rows · not retained in the public archive
2.4 is the ceiling
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg20 months at 2.4 and the honest summary is diminishing returns after the first half
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STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working
i dont think the plateau is a dose problem most of the time, but i cant prove that
half life is about a week so youre roughly four to five weeks to steady state on any new dose
thats STEP 1
is the plateau usually appetite coming back or just the scale stopping
[edited]auckland_aliquotif youre comparing brand to compounded, dose accuracy in the vial is the variable, not…
i stayed on 1.7 for 25 months and never went to 2.4, appetite was already where i needed it
[edited]im 26 months in at 2.5 and the appetite effect faded, is that a thing
[edited]is 2.4 the top or do people go past it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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my dose day drifted from friday to sunday, does that reset anything
steady state takes weeks
£240 a month for compounded against what brand costs locally is why most people here use vials
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sorry to jump in what did SELECT actually measure, i see it quoted for everything
how long did the first 37kg take for people at the low doses
did the STEP 4 withdrawal arm show what i think it showed
lost about 38kg on the low doses before i even got to 1, which surprised me
[edited]five week steps worked better for me than four, purely on how the second week felt
genuine question brand vs compounded, is there a difference people can actually feel
not the same trial
held there too
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
seven days ish
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
dose day is sunday for me only because thats when i remember, not because sunday matters
my PeptideMeter report on the WXT vial came back 99 against a certificate saying 98.1
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
[edited]the long half life flattens the trough more than people expect, i never felt a day seven dip
ok so changed my mind on the four week rule, i think it depends entirely on how the current dose feels
STEP 1 ran to 68 weeks. thats the one everyone half remembers
held at 2 and lost 94lb over 23 months, slower than the trials and fine by me
the plateau hit me at 26 weeks and moved again about a month later without a dose change
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same dose day
update on the earlier thing the appetite effect faded for me around 15 months and going up fixed it for a while
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Batch lookup F-1330: 5 independent reports on file, earliest 2025-05-19.
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i held at 0.25 for 3 months and it was the best decision i made
did anyone titrate slower than four weeks a step and how did that go
genuine question my 30 vial in 0.5ml gives 4mg/ml so 2.4 lands on 15 units, thats why i picked that volume
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
give it four weeks