give it four weeks
#semaglutide 2026-03-28
Saturday33 messages7 participantstimes are UTC
Highlights from this day
- retention_time — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, n of 1 obviously 18:55
- willow_waits — how did people handle the jump from 1 to 1.7 19:08
- retention_time — does moving my dose day by two days matter with a seven day half life 20:09
- willow_waits — quick one 10 months at 2.4 and the honest summary is diminishing returns after the first half 21:13
does anyone actually run a five week step instead of four
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, n of 1 obviously
[edited]✅10❤️15
did anyone titrate slower than four weeks a step and how did that go
plateaus move
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how did people handle the jump from 1 to 1.7
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brand vs compounded, is there a difference people can actually feel
2.4 is the ceiling
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slower worked better
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
the long half life flattens the trough more than people expect, i never felt a day seven dip
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
steady state takes weeks
mine faded too
moving my dose day by a day or two never did anything noticeable for me
went too fast once
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
does moving my dose day by two days matter with a seven day half life
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
not the same trial
i held at 1 for 2 months and it was the best decision i made
[edited]STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
quick one 10 months at 2.4 and the honest summary is diminishing returns after the first half
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgmy 40 vial in 5ml gives 2.5mg/ml so 2 lands on 40 units, thats why i picked that volume
vial units and pen clicks are different systems, mixing the two is how people end up wrong, i think
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Recon calculator: 5mg in 3ml = 10mg/ml.
the appetite effect faded for me around 5 months and going up fixed it for a while
compounded and brand felt the same to me at 0.5, which is one person and nothing more
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
lost about 42kg on the low doses before i even got to 1, which surprised me
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