my 20 vial in 2ml gives 2.5mg/ml so 2.4 lands on 15 units, thats why i picked that volume
weights-monthly.csv
734 rows · not retained in the public archive
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#semaglutide 2026-04-14
Tuesday62 messages13 participantstimes are UTC
Highlights from this day
- egfr_ed — whats the actual licensed ceiling, i keep seeing different numbers 19:44
- a1c_lag — my PeptideMeter report on the KP vial came back 99.4 against a certificate saying 99 19:54
- per_mg_pete — genuine question i held at 10 for 3 months and it was the best decision i made 20:53
- eighteen_months — anyone compared their 5 vial dosing against the pen increments 21:45
- coa_or_cope — sorry to jump in anyone gone from 0.25 straight to 5 or is that too big a jump going slow cost me nothing except time and saved me two bad weeks, thats my whole… 22:27
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
same dose day
half life is about a week so youre roughly four to five weeks to steady state on any new dose
i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
Assay note: TFC lot A-2418 reported at 98.6% of label content.
what did SELECT actually measure, i see it quoted for everything
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did anyone titrate slower than four weeks a step and how did that go
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
went too fast once
compounded and brand felt the same to me at 2.4, which is one person and nothing more
unrelated but dose day is sunday for me only because thats when i remember, not because sunday matters
whats the actual licensed ceiling, i keep seeing different numbers
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19:49marrow.mod pinned a message to this channel
give it four weeks
2.4 is the ceiling
plateaus move
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my PeptideMeter report on the KP vial came back 99.4 against a certificate saying 99
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back after 21 months off, do i restart at 0.25 or somewhere higher
peptidemeter-summary-a-2601.pdf
2 pages · 610 KB · not retained in the public archive
was STEP 4 the one that ran to 68 weeks or am i mixing them up
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
[edited]held there too
does anyone actually run a five week step instead of four
secretagogue_syhalf life is about a week so youre roughly four to five weeks to steady state on any…
moving my dose day by a day or two never did anything noticeable for me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
does the licensed ceiling for weight differ from the diabetes one
coming back to this did anybody find a difference between FGP and pharmacy at the same 5
slower worked better
SELECT wasnt weight
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
weights-monthly.csv
254 rows · not retained in the public archive
i dont think the plateau is a dose problem most of the time, but i cant prove that
is the plateau at 17 weeks normal or am i doing something wrong
did anyone hold at 7.5 longer than four weeks before going up
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
genuine question i held at 10 for 3 months and it was the best decision i made
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held at 5 and lost 48lb over 13 months, slower than the trials and fine by me
mine faded too
€120 a month for compounded against what brand costs locally is why most people here use vials
thats STEP 1
*that should say weekly
the long half life flattens the trough more than people expect, i never felt a day seven dip
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
seven days ish
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the plateau hit me at 7 weeks and moved again about a month later without a dose change
how did people handle the jump from 1 to 1.7
how many weeks before you noticed anything at 2
anyone compared their 5 vial dosing against the pen increments
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
five week steps worked better for me than four, purely on how the second week felt
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the appetite effect faded for me around 18 months and going up fixed it for a while
24 months at 2.4 and the honest summary is diminishing returns after the first half
STEP 1 ran to 68 weeks. thats the one everyone half remembers
Reminder set. I will post here in 6 days.
steady state takes weeks
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not the same trial
genuine question lost about 19kg on the low doses before i even got to 1, which surprised me
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
$120 a month for compounded against what brand costs locally is why most people here use vials
the long half life flattens the trough more than people expect, i never felt a day seven dip
sorry to jump in anyone gone from 0.25 straight to 5 or is that too big a jump
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgvials not pens here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |