anyone at the top dose for over a year and still finding it works, writing this up so want it right
#semaglutide 2026-04-15
Wednesday72 messages14 participantstimes are UTC
Highlights from this day
- step_one_sian — held at 2.4 a long time so the plateau i worried about most turned out to be four weeks of me not weighing anything, ask your prescriber before you change anything.… 17:58
- hydrate_hana — half my plateaus were weeks where i had stopped weighing my food, and i only know that because i checked, not a clinician 18:51
- sulphur_burp — for the sema notes anyone gone from 0.5 straight to 10 or is that too big a jump, or has that changed 20:04
held at 2 a long time so the ladder in the trials is a tolerability schedule and it has been read as a target ever since, which is a shame, that is my read of the paper
four week average
dose day is sunday for me only because thats when i remember, not because sunday matters
plotting a year of this lost about 18kg on the low doses before i even got to 1, which surprised me, in the population they studied
my log has the biggest single drop in the fortnight after a step and then it flattens, every step, same shape, week to week noise is bigger
plotting a year of this my week to week variation is bigger than the difference between two adjacent steps, which took me a long time to accept, in the population they studied
held at 2.4 a long time so the plateau i worried about most turned out to be four weeks of me not weighing anything, ask your prescriber before you change anything. one persons log
i track the tape as well as the scale now, the number moves less and it lies to me less
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
a missed week was not a restart for me, i carried on and the week after felt like a slightly stronger dose, ill know more next month
thats great actually, plot a year of it
small correction to what i said earlier has anyone logged whether the day of the week they inject changes anything, asking because two people told me different things — and anyone tracked weight weekly and seen the stair step pattern
did the cardiovascular result change how anyone thinks about staying on it, been going round in circles on it
not just me then, hold if its working
a stair step weight pattern is what almost everyone who posts a weekly chart here actually sees, not medical advice
on the ladder is there a difference people notice between the branded and the compounded material, no rush
holding at 1 and nausea at a new step usually settles inside two weeks. nausea that does not is worth a conversation with a prescriber
came back down
been meaning to say is STEP 1 the one with the 14 average or am i mixing it up with another, no rush
does the seven day half life mean the last two days are weaker
[edited]about the food noise FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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went back down, reporting is the food noise thing something people notice at 0.25 or only later
i had one lot that reconstituted clear in seconds and one that took a minute, and i have no explanation for either, SELECT was outcomes, not weight
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my resting heart rate went up about five and came back down over the following 14 months, the trial schedule was about tolerability
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, that was week 16 for me
how many weeks before you noticed anything at 5
held there since
half my plateaus were weeks where i had stopped weighing my food, and i only know that because i checked, not a clinician
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four weeks minimum
how do people handle a missed dose day, honestly, anyone
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
not a clinician
is there a reason the 1.7 step gets talked about so little in here, no rush
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week 25 at 1 and did the effect at a given step change over months for anyone — and back after 18 months off, do i restart at 0.25 or somewhere higher
did anybody find a difference between MKM and pharmacy at the same 10
not a clue
coa-c-5033.pdf
1 page · 224 KB · not retained in the public archive
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i log the dose, the date and one sentence, and the pattern only shows up over quarters, the population is not us
genuine ask the appetite effect faded for me around 4 months and going up fixed it for a while, n of 1 as always. thats the label
did anyone find the effect flatter on a smaller more frequent split, or is that a myth in here, trying to get this right before i order
not medical advice but the alcohol thing comes up constantly and there is more anecdote than evidence behind it in this room, that is the licensed ladder anyway
im 20 months in at 1.7 and the appetite effect faded, is that a thing, or should i ask this elsewhere
Assay note: WXT lot B-0114 reported at 99.4% of label content.
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same dose day
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still noisy
is 0.25 genuinely a starting dose or is it only a tolerance step
thats a convention
a hold is a decision. holding at 0.5 for six months because it works is not failing to progress, ask your prescriber before you change anything
tracked this for a while and day six fade is reported often enough to be real for some people and it is not universal, over sixty eight weeks in the study
one for the chart people nothing in my log separates a real plateau from a fortnight of sloppy measurement, and i have looked hard for it, research use only material is not approved for human use
what did SELECT actually measure, i see it quoted for everything
not a weight result
[edited]is the food noise thing described anywhere in the trial write-ups or is that a community term
for the sema notes anyone gone from 0.5 straight to 10 or is that too big a jump, or has that changed
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some people never feel a fade and some feel it every week, both are in this channel and both are logging honestly
while im here the diabetes licence and the weight licence have different ceilings and people quote across them constantly, your mileage will differ
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is 2.4 the top or do people go past it, or is that just me
noting for later does anyone else find the first two days after a shot completely different from the last two
one for the chart people how did people handle the jump from 1 to 1.7, if anyone has a number
one step only
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not medical advice but i lost nothing for five weeks in the middle and then it moved again without me changing a thing, day six fade, for some people
step_one_sianim 20 months in at 1.7 and the appetite effect faded, is that a thing, or should i ask…
went back down, reporting the difference between my best week and my worst week at one dose is bigger than any step change i ever made, n of 1 as always
held there too
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checking i am not mad held at 5 and lost 88lb over 17 months, slower than the trials and fine by me, provisionally
the food noise going quiet was what i noticed first and the scale took another three weeks to agree, in the population they studied. no fade for me
plotting a year of this the trial curves flatten around the same place mine did, which surprised me more than it should have
genuine ask my Medutest report on the SWB vial came back 99, which is where the certificate said it would land
plotting a year of this i sat at 5 for eleven months and it kept working the whole time, and nobody here is a clinician
sort of, shows up over quarters
one persons log
whats the actual licensed ceiling, i keep seeing different numbers
one for the chart people SELECT was a cardiovascular outcomes study and it keeps getting quoted as a weight result, which it is not, im not a chemist. top dose is not a goal
someone else will know
kind of, day two here too