whats the actual licensed ceiling, i keep seeing different numbers
#semaglutide 2026-04-16
Thursday45 messages8 participantstimes are UTC
Highlights from this day
- per_mg_pete — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 19:00
- per_mg_pete — dose day is sunday for me only because thats when i remember, not because sunday matters 19:14
- slow.taper — STEP 1 ran to 68 weeks. thats the one everyone half remembers 19:52
- slow.taper — changed my mind on the four week rule, i think it depends entirely on how the current dose feels, for what its worth 20:07
- triple_ag_tom — im at 1 and stuck, did anyone break a plateau without going up 22:00
quick one is there a reason to hold at 1.7 rather than going to 2.4
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
thats STEP 1
lost about 38kg on the low doses before i even got to 1, which surprised me, for what its worth
give it four weeks
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Reminder for orfor_watch: dose day is today. Set 8 days ago.
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ill dig out the number
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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*week 23 not week 4
vial units and pen clicks are different systems, mixing the two is how people end up wrong
how many weeks before you noticed anything at 12
dose day is sunday for me only because thats when i remember, not because sunday matters
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seven days ish
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does moving my dose day by two days matter with a seven day half life
the plateau hit me at 18 weeks and moved again about a month later without a dose change
held there too
my 20 vial in 5ml gives 5mg/ml so 0.5 lands on 25 units, thats why i picked that volume
slower worked better
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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same dose day
steady state takes weeks
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, for what its worth
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vials not pens here
does the seven day half life mean the last two days are weaker
2.4 is the ceiling
STEP is several trials, so saying STEP said x is usually wrong without a number after it, from memory
how did people handle the jump from 1 to 1.7
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what did SELECT actually measure, i see it quoted for everything
i stayed on 1.7 for 21 months and never went to 2.4, appetite was already where i needed it, i could be wrong
anyone compared their 5 vial dosing against the pen increments
compounded and brand felt the same to me at 1.7, which is one person and nothing more
the long half life flattens the trough more than people expect, i never felt a day seven dip
genuine question restarted after 14 months off at a low dose and the nausea arrived exactly like the first time, i could be wrong
does anyone actually run a five week step instead of four
half life is about a week so youre roughly four to five weeks to steady state on any new dose
im 22 months in at 7.5 and the appetite effect faded, is that a thing
im at 1 and stuck, did anyone break a plateau without going up
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
did anybody find a difference between QSC and pharmacy at the same 0.5
mine faded too
the appetite effect faded for me around 5 months and going up fixed it for a while
compounded and brand felt the same to me at 0.25, which is one person and nothing more
Batch lookup A-2418: 3 independent reports on file, earliest 2025-12-30.
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