the appetite effect faded for me around 14 months and going up fixed it for a while
#semaglutide 2026-05-07
Thursday29 messages7 participantstimes are UTC
Highlights from this day
- rezept_rolf — right so my 5 vial in 5ml gives 2mg/ml so 2.4 lands on 12 units, thats why i picked that volume 10:46
- lyophile_liv — 16 months at 2.4 and the honest summary is diminishing returns after the first half, thats just me 11:23
- lisbon_lot — genuine question my VendorInvestigate report on the QST vial came back 97.4 against a certificate saying 98.1 12:00
- lisbon_lot — did anyone titrate slower than four weeks a step and how did that go 13:39
- food_noise_off — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 21:13
steady state takes weeks
mine faded too
vials not pens here
dose day is sunday for me only because thats when i remember, not because sunday matters
restarted after 12 months off at a low dose and the nausea arrived exactly like the first time
held there too
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right so my 5 vial in 5ml gives 2mg/ml so 2.4 lands on 12 units, thats why i picked that volume
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
what did SELECT actually measure, i see it quoted for everything
16 months at 2.4 and the honest summary is diminishing returns after the first half, thats just me
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genuine question FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
went too fast once
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genuine question my VendorInvestigate report on the QST vial came back 97.4 against a certificate saying 98.1
half life is about a week so youre roughly four to five weeks to steady state on any new dose
thats STEP 1
same dose day
give it four weeks
€55 a month for compounded against what brand costs locally is why most people here use vials
brand vs compounded, is there a difference people can actually feel
did anyone titrate slower than four weeks a step and how did that go
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SELECT wasnt weight
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the long half life flattens the trough more than people expect, i never felt a day seven dip
does anyone actually run a five week step instead of four
sorry to jump in STEP 1 ran to 68 weeks. thats the one everyone half remembers
is the plateau at 24 weeks normal or am i doing something wrong
whats the actual licensed ceiling, i keep seeing different numbers
my dose day drifted from friday to sunday, does that reset anything
[edited]licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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