the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
#semaglutide 2026-05-08
Friday58 messages16 participantstimes are UTC
Highlights from this day
- VialBot — Batch lookup B-0114: 8 independent reports on file, earliest 2025-09-12. 21:19
- turnaround_tam — does the seven day half life mean the last two days are weaker dose day is sunday for me only because thats when i remember, not because sunday matters 21:43
- turnaround_tam — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 22:07
held at 5 and lost 80lb over 2 months, slower than the trials and fine by me
lost about 31kg on the low doses before i even got to 1, which surprised me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
25 months at 2.4 and the honest summary is diminishing returns after the first half
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my PeptideMeter report on the SSA vial came back 99.2 against a certificate saying 98.1
anyone gone from 2 straight to 7.5 or is that too big a jump
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i dont think the plateau is a dose problem most of the time, but i cant prove that
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, anyway
does moving my dose day by two days matter with a seven day half life
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwas SELECT the one that ran to 68 weeks or am i mixing them up
the appetite effect faded for me around 16 months and going up fixed it for a while, happy to be corrected
did anybody find a difference between ERP and pharmacy at the same 2.4
SELECT wasnt weight
right so back after 18 months off, do i restart at 0.25 or somewhere higher
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held there too
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgok so i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does anyone actually run a five week step instead of four
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ill dig out the number
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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2.4 is the ceiling
restarted after 25 months off at a low dose and the nausea arrived exactly like the first time
*PeptideMeter not the other one
steady state takes weeks
coming back to this steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
dose day is sunday for me only because thats when i remember, not because sunday matters, ask me again in a month
i held at 12 for 2 months and it was the best decision i made
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my dose day drifted from friday to sunday, does that reset anything
ok so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
the plateau hit me at 27 weeks and moved again about a month later without a dose change
i stayed on 1.7 for 22 months and never went to 2.4, appetite was already where i needed it
mine faded too
moving my dose day by a day or two never did anything noticeable for me
the appetite effect faded for me around 10 months and going up fixed it for a while
im at 0.5 and stuck, did anyone break a plateau without going up
compounded and brand felt the same to me at 2.4, which is one person and nothing more, still working it out
follow up vial units and pen clicks are different systems, mixing the two is how people end up wrong
Batch lookup B-0114: 8 independent reports on file, earliest 2025-09-12.
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thats STEP 1
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ask me again in a month
give it four weeks
is the plateau usually appetite coming back or just the scale stopping
vials not pens here
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does the seven day half life mean the last two days are weaker
dose day is sunday for me only because thats when i remember, not because sunday matters
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went too fast once
the plateau hit me at 15 weeks and moved again about a month later without a dose change, i could be wrong
brand vs compounded, is there a difference people can actually feel
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
five week steps worked better for me than four, purely on how the second week felt, n of 1 obviously
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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how long till steady state, ive read the half life is about a week
sorry to jump in anyone compared their 5 vial dosing against the pen increments
not the same trial
plateaus move
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
same dose day
seven days ish
$94 a month for compounded against what brand costs locally is why most people here use vials