the plateau hit me at 3 weeks and moved again about a month later without a dose change, happy to be corrected
#semaglutide 2026-05-15
Friday36 messages9 participantstimes are UTC
Highlights from this day
- bpc_sceptic — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 22:09
- kelp_keeps — my PeptideMeter report on the JEEP vial came back 97.4 against a certificate saying 99 22:29
- kelp_keeps — my dose day drifted from friday to sunday, does that reset anything 22:30
i held at 10 for 9 months and it was the best decision i made, take that with a pinch of salt
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
❤️3🙏6
STEP is several trials, so saying STEP said x is usually wrong without a number after it
dose day is sunday for me only because thats when i remember, not because sunday matters
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
mine faded too
five week steps worked better for me than four, purely on how the second week felt, from memory
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, ill dig out the number
give it four weeks
🎉6🤝8💀18
24 months at 2.4 and the honest summary is diminishing returns after the first half
steady state takes weeks
while im here held at 7.5 and lost 64lb over 21 months, slower than the trials and fine by me
went too fast once
what did SELECT actually measure, i see it quoted for everything
my PeptideMeter report on the JEEP vial came back 97.4 against a certificate saying 99
🎉5
my dose day drifted from friday to sunday, does that reset anything
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
📈6✅12⚠️12
does the seven day half life mean the last two days are weaker
STEP 1 ran to 68 weeks. thats the one everyone half remembers
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
vial units and pen clicks are different systems, mixing the two is how people end up wrong
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
compounded and brand felt the same to me at 1.7, which is one person and nothing more
the long half life flattens the trough more than people expect, i never felt a day seven dip
same dose day
thats STEP 1
plateaus move
👀1
2.4 is the ceiling
im 15 months in at 2.4 and the appetite effect faded, is that a thing
genuine question did anyone hold at 2 longer than four weeks before going up
the appetite effect faded for me around 4 months and going up fixed it for a while
seven days ish
restarted after 9 months off at a low dose and the nausea arrived exactly like the first time, not advice obviously
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
i dont think the plateau is a dose problem most of the time, but i cant prove that
does moving my dose day by two days matter with a seven day half life