2.4 is the ceiling
#semaglutide 2026-05-26
Tuesday33 messages6 participantstimes are UTC
Highlights from this day
- sol_sends — lost about 4kg on the low doses before i even got to 1, which surprised me 16:33
- two_four_ceiling — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 16:40
- two_four_ceiling — my Janoshik report on the FGP vial came back 97.4 against a certificate saying 98.1 16:44
- two_four_ceiling — update on the earlier thing how long till steady state, ive read the half life is about a week 16:51
- egfr_ed — i dont think the plateau is a dose problem most of the time, but i cant prove that, someone check my working 18:23
lost about 4kg on the low doses before i even got to 1, which surprised me
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg€120 a month for compounded against what brand costs locally is why most people here use vials, anyway
i dont think the plateau is a dose problem most of the time, but i cant prove that
my Janoshik report on the FGP vial came back 97.4 against a certificate saying 98.1
fridge-temps.csv
142 rows · not retained in the public archive
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how did people handle the jump from 1 to 1.7
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the plateau hit me at 27 weeks and moved again about a month later without a dose change
the long half life flattens the trough more than people expect, i never felt a day seven dip
update on the earlier thing how long till steady state, ive read the half life is about a week
✅8❤️10🧊3
thats STEP 1
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
whats the actual licensed ceiling, i keep seeing different numbers
compounded and brand felt the same to me at 12, which is one person and nothing more
Digest for the week of 2026-03-10 has been published.
SELECT wasnt weight
for the archive anyone compared their 4 vial dosing against the pen increments
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
brand vs compounded, is there a difference people can actually feel
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
i dont think the plateau is a dose problem most of the time, but i cant prove that, someone check my working
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is the plateau usually appetite coming back or just the scale stopping
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i held at 12 for 9 months and it was the best decision i made
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
while im here SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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held there too
did anyone hold at 1 longer than four weeks before going up
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
mine faded too
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did the STEP 4 withdrawal arm show what i think it showed
[edited]went too fast once
im 21 months in at 0.5 and the appetite effect faded, is that a thing
how many weeks before you noticed anything at 0.25
dose day is sunday for me only because thats when i remember, not because sunday matters