i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
#semaglutide 2026-05-27
Wednesday61 messages13 participantstimes are UTC
Highlights from this day
- half_life_hal — ok so compounded and brand felt the same to me at 10, which is one person and nothing more 12:22
- travel_cooler — right so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 12:31
- juno_joins — whats the actual licensed ceiling, i keep seeing different numbers 14:20
- egfr_ed — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, still working it out 17:08
held there too
how did people handle the jump from 1 to 1.7
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steady state takes weeks
does the licensed ceiling for weight differ from the diabetes one
ok so is 2.4 the top or do people go past it
ok so compounded and brand felt the same to me at 10, which is one person and nothing more
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not the same trial
lost about 31kg on the low doses before i even got to 1, which surprised me, ymmv
right so FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, happy to be corrected
fridge-temps.csv
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anyone compared their 10 vial dosing against the pen increments
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right so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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right so restarted after 25 months off at a low dose and the nausea arrived exactly like the first time, i could be wrong
my dose day drifted from friday to sunday, does that reset anything
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
plateaus move
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SELECT wasnt weight
for the archive going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, take that with a pinch of salt
back after 16 months off, do i restart at 0.25 or somewhere higher
give it four weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
unrelated but my PeptideMeter report on the QSC vial came back 99 against a certificate saying 98.1
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
same dose day
[edited]my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
five week steps worked better for me than four, purely on how the second week felt
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STEP 1 ran to 68 weeks. thats the one everyone half remembers, ask me again in a month
how many weeks before you noticed anything at 1.7
the appetite effect faded for me around 8 months and going up fixed it for a while
STEP is several trials, so saying STEP said x is usually wrong without a number after it
whats the actual licensed ceiling, i keep seeing different numbers
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
how long till steady state, ive read the half life is about a week
i held at 5 for 4 months and it was the best decision i made
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
vials not pens here
vial-e-2205-front.png
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im at 2 and stuck, did anyone break a plateau without going up
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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does the seven day half life mean the last two days are weaker
slower worked better
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
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mine faded too
is the plateau usually appetite coming back or just the scale stopping
what did SELECT actually measure, i see it quoted for everything
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
2.4 is the ceiling
$72 a month for compounded against what brand costs locally is why most people here use vials
the plateau hit me at 22 weeks and moved again about a month later without a dose change
moving my dose day by a day or two never did anything noticeable for me
genuine question half life is about a week so youre roughly four to five weeks to steady state on any new dose
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On this day 3 years ago this channel logged 131 messages.
did anyone hold at 2.4 longer than four weeks before going up
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the long half life flattens the trough more than people expect, i never felt a day seven dip
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held at 15 and lost 69lb over 4 months, slower than the trials and fine by me
my 30 vial in 3ml gives 8mg/ml so 1 lands on 5 units, thats why i picked that volume
thats STEP 1
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, still working it out
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
STEP 1 ran to 68 weeks. thats the one everyone half remembers
does moving my dose day by two days matter with a seven day half life
2 months at 2.4 and the honest summary is diminishing returns after the first half
i dont think the plateau is a dose problem most of the time, but i cant prove that
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
plateaus move
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