i stayed on 1.7 for 14 months and never went to 2.4, appetite was already where i needed it
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#semaglutide 2026-06-06
Saturday79 messages15 participantstimes are UTC
Highlights from this day
- coa_or_cope — i stayed on 1.7 for 14 months and never went to 2.4, appetite was already where i needed it 10:15
- coa_or_cope — vial units and pen clicks are different systems, mixing the two is how people end up wrong 10:50
- chlorhex — slightly off topic but my dose day drifted from friday to sunday, does that reset anything 12:47
compounded and brand felt the same to me at 2, which is one person and nothing more
what did SELECT actually measure, i see it quoted for everything
back after 25 months off, do i restart at 0.25 or somewhere higher
moving my dose day by a day or two never did anything noticeable for me
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, thats just me
restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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did anybody find a difference between HJ and pharmacy at the same 0.25
the long half life flattens the trough more than people expect, i never felt a day seven dip
[edited]follow up my Medutest report on the CPC vial came back 99 against a certificate saying 98.6
went too fast once
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how long till steady state, ive read the half life is about a week
five week steps worked better for me than four, purely on how the second week felt
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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does moving my dose day by two days matter with a seven day half life
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quick one STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, for what its worth
the appetite effect faded for me around 9 months and going up fixed it for a while
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how did people handle the jump from 1 to 1.7
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
anyone gone from 2.4 straight to 1 or is that too big a jump
is the plateau usually appetite coming back or just the scale stopping
while im here STEP 1 ran to 68 weeks. thats the one everyone half remembers
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
slightly off topic but my dose day drifted from friday to sunday, does that reset anything
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my 40 vial in 1ml gives 4mg/ml so 1.7 lands on 8 units, thats why i picked that volume, thats just me
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
same dose day
mine faded too
does anyone actually run a five week step instead of four
is there a reason to hold at 1.7 rather than going to 2.4
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
is the plateau at 19 weeks normal or am i doing something wrong
held there too
seven days ish
lost about 26kg on the low doses before i even got to 1, which surprised me, ill dig out the number
i held at 12 for 2 months and it was the best decision i made
how many weeks before you noticed anything at 7.5
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genuine question held at 1 and lost 27lb over 6 months, slower than the trials and fine by me
im 13 months in at 1 and the appetite effect faded, is that a thing
thats STEP 1
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
steady state takes weeks
follow up €240 a month for compounded against what brand costs locally is why most people here use vials
give it four weeks
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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SELECT wasnt weight
slower worked better
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, ill dig out the number
plateaus move
2.4 is the ceiling
does the seven day half life mean the last two days are weaker
update on the earlier thing if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
im at 1 and stuck, did anyone break a plateau without going up
how long did the first 10kg take for people at the low doses
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ill dig out the number
vials not pens here
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not the same trial, n of 1 obviously
dose day is sunday for me only because thats when i remember, not because sunday matters
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half life is about a week so youre roughly four to five weeks to steady state on any new dose, for what its worth
*week 16 not week 9
STEP is several trials, so saying STEP said x is usually wrong without a number after it
the plateau hit me at 24 weeks and moved again about a month later without a dose change
thats STEP 1
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16:58tenpence pinned a message
follow up did the STEP 4 withdrawal arm show what i think it showed
sorry to jump in 13 months at 2.4 and the honest summary is diminishing returns after the first half
vial units and pen clicks are different systems, mixing the two is how people end up wrong
plateaus move, from memory
was STEP 1 the one that ran to 68 weeks or am i mixing them up
i held at 2 for 9 months and it was the best decision i made
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdid anyone titrate slower than four weeks a step and how did that go
give it four weeks
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same dose day
while im here i dont think the plateau is a dose problem most of the time, but i cant prove that
does the licensed ceiling for weight differ from the diabetes one
Reminder for nim_new: dose day is today. Set 6 days ago.
same dose day
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