slightly off topic but how many weeks before you noticed anything at 2.5
😂6🎉1🤝10
#semaglutide 2026-06-07
Sunday32 messages9 participantstimes are UTC
Highlights from this day
- two_four_ceiling — did anyone hold at 12 longer than four weeks before going up 19:09
- pine_pins — dose day is sunday for me only because thats when i remember, not because sunday matters 19:56
- vienna_vial — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 21:12
- a1c_lag — while im here my 5 vial in 2.5ml gives 10mg/ml so 1 lands on 12 units, thats why i picked that volume 21:53
- quiet.hours — lost about 24kg on the low doses before i even got to 1, which surprised me 21:56
follow up SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
steady state takes weeks
❤️6✅15📉11
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my dose day drifted from friday to sunday, does that reset anything
did anyone hold at 12 longer than four weeks before going up
🎉8🤝10
STEP 1 ran to 68 weeks. thats the one everyone half remembers
👀1🔥13😂2
is the plateau usually appetite coming back or just the scale stopping
thats STEP 1
same dose day
went too fast once
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
dose day is sunday for me only because thats when i remember, not because sunday matters
✅12👀5📉1
is the plateau at 11 weeks normal or am i doing something wrong
compounded and brand felt the same to me at 12, which is one person and nothing more
📈8📉1🧪2
10 months at 2.4 and the honest summary is diminishing returns after the first half
mine faded too
right so did anyone titrate slower than four weeks a step and how did that go
give it four weeks
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
🧪18
plateaus move
half life is about a week so youre roughly four to five weeks to steady state on any new dose
seven days ish
does anyone actually run a five week step instead of four
for the archive my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
vial-d-0718-front.png
900 × 1200 · 307 KB · not retained in the public archive
slower worked better
the long half life flattens the trough more than people expect, i never felt a day seven dip
Archive lookup: quiet.hours first appears in this channel on 2025-11-30.
while im here my 5 vial in 2.5ml gives 10mg/ml so 1 lands on 12 units, thats why i picked that volume
🧪10👍6🧊4
how long did the first 10kg take for people at the low doses
lost about 24kg on the low doses before i even got to 1, which surprised me
[edited]🎉12⚠️14