what did SELECT actually measure, i see it quoted for everything
#semaglutide 2026-06-14
Sunday69 messages11 participantstimes are UTC
Highlights from this day
- rotate_the_site — i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it 18:57
- nordic_price_nils — the plateau hit me at 28 weeks and moved again about a month later without a dose change 20:09
- nadia_notes — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 21:54
moving my dose day by a day or two never did anything noticeable for me
held at 0.25 and lost 26lb over 4 months, slower than the trials and fine by me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
i held at 2.4 for 4 months and it was the best decision i made, not advice obviously
held there too
did anyone hold at 5 longer than four weeks before going up
anyone compared their 2.5 vial dosing against the pen increments
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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2.4 is the ceiling
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
is there a reason to hold at 1.7 rather than going to 2.4
quick one anyone gone from 2.4 straight to 12 or is that too big a jump
i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
the long half life flattens the trough more than people expect, i never felt a day seven dip
dose day is sunday for me only because thats when i remember, not because sunday matters
unrelated but if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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plateaus move
not the same trial
im at 2.5 and stuck, did anyone break a plateau without going up
compounded and brand felt the same to me at 1, which is one person and nothing more
is the plateau usually appetite coming back or just the scale stopping
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thats STEP 1
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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same dose day
the appetite effect faded for me around 12 months and going up fixed it for a while
my 40 vial in 5ml gives 2mg/ml so 2.5 lands on 5 units, thats why i picked that volume
steady state takes weeks
restarted after 16 months off at a low dose and the nausea arrived exactly like the first time
i dont think the plateau is a dose problem most of the time, but i cant prove that
did anyone titrate slower than four weeks a step and how did that go
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
unrelated but my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
while im here 20 months at 2.4 and the honest summary is diminishing returns after the first half
the plateau hit me at 28 weeks and moved again about a month later without a dose change
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does anyone actually run a five week step instead of four
lost about 14kg on the low doses before i even got to 1, which surprised me
my Medutest report on the WWB vial came back 97.4 against a certificate saying 98.6, n of 1 obviously
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
went too fast once
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unrelated but five week steps worked better for me than four, purely on how the second week felt
did the STEP 4 withdrawal arm show what i think it showed
seven days ish
unrelated but SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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slower worked better
vial units and pen clicks are different systems, mixing the two is how people end up wrong
my 10 vial in 1ml gives 2.5mg/ml so 12 lands on 20 units, thats why i picked that volume
follow up mine faded too
dose day is sunday for me only because thats when i remember, not because sunday matters, thats just me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
how long till steady state, ive read the half life is about a week
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis the plateau at 2 weeks normal or am i doing something wrong
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
is 2.4 the top or do people go past it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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€240 a month for compounded against what brand costs locally is why most people here use vials
vials not pens here
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does moving my dose day by two days matter with a seven day half life
brand vs compounded, is there a difference people can actually feel
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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how long did the first 35kg take for people at the low doses
genuine question give it four weeks
Archive lookup: cagri_curious first appears in this channel on 2025-10-31.
SELECT wasnt weight
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
how did people handle the jump from 1 to 1.7