did the STEP 4 withdrawal arm show what i think it showed
#semaglutide 2026-06-15
Monday33 messages8 participantstimes are UTC
Highlights from this day
- jute_journals — brand vs compounded, is there a difference people can actually feel 11:01
- dill_doses — anyone gone from 12 straight to 1.7 or is that too big a jump 11:17
- identity_shift — does the licensed ceiling for weight differ from the diabetes one 12:33
- identity_shift — my 30 vial in 5ml gives 2.5mg/ml so 2.4 lands on 50 units, thats why i picked that volume 13:10
does the seven day half life mean the last two days are weaker
brand vs compounded, is there a difference people can actually feel
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Digest for the week of 2026-03-02 has been published.
the long half life flattens the trough more than people expect, i never felt a day seven dip
seven days ish
anyone gone from 12 straight to 1.7 or is that too big a jump
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgis the plateau usually appetite coming back or just the scale stopping
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, n of 1 obviously
Purity check: no report on file for lot A-2418. Nothing logged either way.
did anybody find a difference between GL Biochem and pharmacy at the same 2
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, for what its worth
unrelated but vial units and pen clicks are different systems, mixing the two is how people end up wrong
i held at 5 for 5 months and it was the best decision i made
does the licensed ceiling for weight differ from the diabetes one
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held at 0.25 and lost 19lb over 13 months, slower than the trials and fine by me, anyway
my 30 vial in 5ml gives 2.5mg/ml so 2.4 lands on 50 units, thats why i picked that volume
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
unrelated but is the plateau at 3 weeks normal or am i doing something wrong
was FLOW the one that ran to 68 weeks or am i mixing them up
is there a reason to hold at 1.7 rather than going to 2.4
steady state takes weeks
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
restarted after 5 months off at a low dose and the nausea arrived exactly like the first time, not advice obviously
give it four weeks
£72 a month for compounded against what brand costs locally is why most people here use vials
STEP 1 ran to 68 weeks. thats the one everyone half remembers
coming back to this im at 0.25 and stuck, did anyone break a plateau without going up
SELECT wasnt weight
for the archive the plateau hit me at 27 weeks and moved again about a month later without a dose change
same dose day