im at 2.5 and stuck, did anyone break a plateau without going up
#semaglutide 2026-06-24
Wednesday51 messages11 participantstimes are UTC
Highlights from this day
- septum_sal — how many weeks before you noticed anything at 10 vial units and pen clicks are different systems, mixing the two is how people end up wrong 22:14
- lean_mass_lex — im 9 months in at 12 and the appetite effect faded, is that a thing 22:33
- lean_mass_lex — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 22:56
- rezept_rolf — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 23:19
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
26 months at 2.4 and the honest summary is diminishing returns after the first half
how many weeks before you noticed anything at 10
vial units and pen clicks are different systems, mixing the two is how people end up wrong
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🤝2👀18✅5
does anyone actually run a five week step instead of four
same dose day
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did anybody find a difference between WXT and pharmacy at the same 5
five week steps worked better for me than four, purely on how the second week felt
held at 2.5 and lost 14lb over 24 months, slower than the trials and fine by me, ask me again in a month
my Medutest report on the WXT vial came back 98.6 against a certificate saying 99.2, anyway
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
im 9 months in at 12 and the appetite effect faded, is that a thing
📈1⚠️14🎉17
i dont think the plateau is a dose problem most of the time, but i cant prove that
held there too
follow up restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
vial-f-1330-front.png
900 × 1200 · 88 KB · not retained in the public archive
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the appetite effect faded for me around 20 months and going up fixed it for a while
what did SELECT actually measure, i see it quoted for everything
update on the earlier thing anyone compared their 10 vial dosing against the pen increments
i stayed on 1.7 for 26 months and never went to 2.4, appetite was already where i needed it
anyone gone from 2.5 straight to 0.25 or is that too big a jump
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
thats STEP 1
went too fast once
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
🙏5🎉1😂12
did anyone titrate slower than four weeks a step and how did that go
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
👍10
how long did the first 6kg take for people at the low doses
back after 5 months off, do i restart at 0.25 or somewhere higher
😂1👀9
dose day is sunday for me only because thats when i remember, not because sunday matters
New independent result logged — CPC, lot C-4402, purity 97.4% (PeptideMeter).
is the plateau usually appetite coming back or just the scale stopping
[edited]did anyone hold at 1 longer than four weeks before going up
quick one moving my dose day by a day or two never did anything noticeable for me
my 30 vial in 1.5ml gives 8mg/ml so 15 lands on 15 units, thats why i picked that volume
the plateau hit me at 14 weeks and moved again about a month later without a dose change
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
📈1👍6😂6
i held at 2 for 5 months and it was the best decision i made
genuine question how did people handle the jump from 1 to 1.7
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
slightly off topic but STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
slower worked better
not the same trial
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mglost about 31kg on the low doses before i even got to 1, which surprised me, ymmv
£94 a month for compounded against what brand costs locally is why most people here use vials
plateaus move
Verification log updated: GGPeps — evidence added, status unchanged.
steady state takes weeks