not the same trial
#semaglutide 2026-06-25
Thursday17 messages4 participantstimes are UTC
Highlights from this day
- VialBot — On this day 4 years ago this channel logged 70 messages. 19:32
- reta_resting_hr — back after 20 months off, do i restart at 0.25 or somewhere higher 20:23
- reta_resting_hr — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, take that with a pinch of salt 20:26
- reta_resting_hr — STEP is several trials, so saying STEP said x is usually wrong without a number after it 20:27
genuine question moving my dose day by a day or two never did anything noticeable for me, i have it written down somewhere
im 3 months in at 2.5 and the appetite effect faded, is that a thing
same dose day
give it four weeks
plateaus move
how long till steady state, ive read the half life is about a week
the long half life flattens the trough more than people expect, i never felt a day seven dip, anyway
vial units and pen clicks are different systems, mixing the two is how people end up wrong
mine faded too
does the seven day half life mean the last two days are weaker
the plateau hit me at 19 weeks and moved again about a month later without a dose change
On this day 4 years ago this channel logged 70 messages.
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was STEP 1 the one that ran to 68 weeks or am i mixing them up
back after 20 months off, do i restart at 0.25 or somewhere higher
🤝11🧪17🎉2
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, take that with a pinch of salt
STEP is several trials, so saying STEP said x is usually wrong without a number after it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |