i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
#storage-coldchain 2025-08-21
Thursday24 messages7 participantstimes are UTC
Highlights from this day
- rotterdam_recon — while im here lyophilised at room temp for 9 days in transit, worried or not 19:53
- VialBot — Testing queue: 9 submissions open, 48 awaiting dispatch. 19:55
- rotterdam_recon — lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear, ask me again in a month 20:22
- hot_mailbox — anyone tested a vial before and after a bad transit 20:26
- verify_or_dont — two to eight degrees. most domestic fridge doors are not in that range and people do not check 21:05
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
my fridge is 5.6
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follow up my fridge is running at 6.2, is that out of range
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
powder is robust
nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
coming back to this a liquid cold pack tells you it was above freezing, not that your vial cooked
i log the fridge temperature daily and the room has never let me forget it
while im here lyophilised at room temp for 9 days in transit, worried or not
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Testing queue: 9 submissions open, 48 awaiting dispatch.
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a cooler with two gel packs held under eight degrees for eleven hours on a drive
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update from 24 months ago: replaced the fridge, temperature is stable, no more anxiety
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear, ask me again in a month
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quick one do you keep the unopened vials and the in-use one in the same place
parcel sat in a hot mailbox for 5 hours, is it dead
anyone tested a vial before and after a bad transit
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ok so i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
buy a thermometer. mine reads 6.2 on the door and two degrees lower at the back, n of 1 obviously
power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
cricket_or_footyi have never had a lyophilised vial fail after a warm transit and i have had some bad…
what temperature does a domestic fridge door actually swing to
two to eight degrees. most domestic fridge doors are not in that range and people do not check
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does anyone freeze reconstituted vials or is that madness
quick one the vial that visibly changed after a warm transit was the one that had already been reconstituted
right so freeze thaw cycling is the risk, not one freeze. that is my read of it anyway