freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
#storage-coldchain 2025-08-22
Friday31 messages6 participantstimes are UTC
Highlights from this day
- no_escrow_nate — hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct 13:19
- septum_sal — i log the fridge temperature daily and the room has never let me forget it 17:50
- septum_sal — for flying, hand luggage every time. the hold is not temperature controlled the way people assume 17:58
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
slightly off topic but a liquid cold pack tells you it was above freezing, not that your vial cooked, not advice obviously
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
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update from 9 months ago: replaced the fridge, temperature is stable, no more anxiety
the vial that visibly changed after a warm transit was the one that had already been reconstituted
genuine question nobody here can tell you a vial is safe. we can tell you what has and has not survived for us, not advice obviously
powder is robust
slightly off topic but power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well, thats just me
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
thats fine
do you keep the unopened vials and the in-use one in the same place
test it
back of the fridge
*Janoshik not the other one
log it
do i need to worry about light exposure or is that overthinking
i would bin it
a cooler with two gel packs held under eight degrees for eleven hours on a drive
right so anyone tested a vial before and after a bad transit
solution is not
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
not the door
i log the fridge temperature daily and the room has never let me forget it
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the door swings four or five degrees every time somebody opens it. the back barely moves
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two to eight degrees. most domestic fridge doors are not in that range and people do not check
nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
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Batch lookup H-2814: 8 independent reports on file, earliest 2025-05-11.
power cut for 7 hours, fridge stayed shut, am i fine
slightly off topic but i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why