a liquid cold pack tells you it was above freezing, not that your vial cooked
#storage-coldchain 2026-05-14
Thursday31 messages7 participantstimes are UTC
Highlights from this day
- chain_of_custody — how do you keep it cold on a long drive in summer 22:48
- group_buy_gwen — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine 22:56
- mag_citrate — coming back to this unopened and in-use in the same place is fine. just keep the in-use one where you can reach it 23:26
two to eight
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gel packs
the door swings four or five degrees every time somebody opens it. the back barely moves
Inter-lab diff for lot KP-0925: 96.8% vs 98.1%. Within expected range.
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
parcel sat in a hot mailbox for 9 hours, is it dead
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear, thats one data point
thats fine
i keep everything at the back of the middle shelf, never the door
if you are worried after a bad transit, test it. that is what the testing channels are for
is a five pound fridge thermometer actually worth it
two to eight degrees. most domestic fridge doors are not in that range and people do not check
back of the fridge
not the freezer
what temperature does a domestic fridge door actually swing to
i would use it
powder is robust
update from 21 months ago: replaced the fridge, temperature is stable, no more anxiety
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how do you keep it cold on a long drive in summer
fridge-temps.csv
893 rows · not retained in the public archive
does the fridge in a hotel room count as a fridge
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
solution is not
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buy a thermometer. mine reads 7.4 on the door and two degrees lower at the back
a few hours at room temperature is almost certainly nothing. a week is a different conversation
buy a thermometer
coming back to this unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
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power cut for 5 hours, fridge stayed shut, am i fine
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
lyophilised at room temp for 4 days in transit, worried or not