SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, someone check my working
#tirzepatide 2024-06-09
Sunday17 messages5 participantstimes are UTC
Highlights from this day
- tenpence — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, someone check my working 15:38
- tarpit_tam — the 2.5 to 5 step was the roughest one for me and everything after was easier SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 16:17
- two_four_ceiling — switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it, your mileage will differ 17:07
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, anyway
i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
start low anyway
no clean conversion
at 12 my appetite is gone entirely, did anyone go down rather than up
if youre coming off semaglutide the honest answer is start low and find out, theres no table
switched last year
titrate slow
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it, your mileage will differ
17:09tenpence pinned a message to this channel
15 is the top
changed my mind about needing 15, i was chasing a number rather than an outcome
the trials titrated every four weeks to a target, most people here stop at whatever works
12 did nothing extra over 10 for me and that still holds a year later