Digest for the week of 2024-01-01 has been published.
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#tirzepatide 2024-06-15
Saturday41 messages11 participantstimes are UTC
Highlights from this day
- ferrous_ash — does the GIP arm actually explain the easier nausea or is that hand waving 19:03
- gradient_greg — i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more 20:05
- nhs_pathway_nell — the sweet spot thing is survivorship, the people it worked for stayed and said so 21:20
- nhs_pathway_nell — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 21:31
- noct.titrate — restarted at 2.5 after 4 months off and the first two doses reminded me why titration exists 22:33
the switch felt like a step down at first and then caught up around week 9
5 did nothing
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
is SURMOUNT-OSA the sleep apnoea one
does the GIP arm actually explain the easier nausea or is that hand waving
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i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from
folklore probably
is there a reason to titrate slower than the four week schedule
coming off semaglutide, is there a conversion or do i restart at 2.5
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the trials titrated every four weeks to a target, most people here stop at whatever works, anyway
same plateau here
GIP plus GLP-1
12 did nothing extra over 10 for me and that still holds a year later
did going from 10 semaglutide to 5 of this feel like a step down for anyone
$38 for a 2 vial is roughly what ive paid for the last year
quick one how many weeks at 7.5 before you knew it was enough
*week 19 not week 2
i argued the sweet spot was nonsense and then spent 20 months at 7.5 not needing more
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Recon calculator: 30mg in 0.5ml = 2.5mg/ml.
easier gi for me
SURMOUNT is weight
genuine question SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
my PeptideMeter result on a WWB vial came in at 99 which is why i keep buying from them, for what its worth
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
20:43ferrous_ash pinned a message
switched last year
40 units of a 2 solution is a lot of volume and i check that one twice every single time, ill dig out the number
the GI difference held for me right up to 15, which isnt what a couple of people here found
did anyone find the GI easier than semaglutide at an equivalent effect
i went to 15 and came back to 10, more suppression wasnt more useful for me
at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win
the sweet spot thing is survivorship, the people it worked for stayed and said so
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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10 was enough
did anyone go past 15 and was there any point to it
titrate slow
changed my mind about needing 15, i was chasing a number rather than an outcome
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the sweet spot argument is really about effect per side effect, not a magic number, someone check my working
7.5 gang
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restarted at 2.5 after 4 months off and the first two doses reminded me why titration exists
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