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#tirzepatide 2024-09-08

Sunday45 messages11 participantstimes are UTC
Highlights from this day
  • VialBot — Inter-lab diff for lot SG-1177: 98.6% vs 99.2%. Within expected range. 22:26
  • bolus_bo — im at 2.4 and thinking about 5, did anyone gain anything from that step 23:27
  • bolus_bo — genuine question my Medutest result on a JEEP vial came in at 99.2 which is why i keep buying from them at 10 my appetite went completely and i dropped back a step,… 23:30
  • peak_split — anyone stopped at 10 and stayed there for months 23:58
PS

anyone tracked whether the GI difference held at the top doses

TT

the 2.5 to 5 step was the roughest one for me and everything after was easier, happy to be corrected

[edited]
VB

Inter-lab diff for lot SG-1177: 98.6% vs 99.2%. Within expected range.

🎉14

is the sweet spot argument about effect or about side effects
the GI difference held for me right up to 15, which isnt what a couple of people here found

at 2.4 my appetite is gone entirely, did anyone go down rather than up
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win

the 10 vial in 2.5ml gives 4mg/ml which puts 5 on 10 units, nice round numbers

👀1

GIP plus GLP-1

TT

is 7.5 really the sweet spot or is that just channel folklore

is SURMOUNT-OSA the sleep apnoea one

folklore probably

the sweet spot thing is survivorship, the people it worked for stayed and said so

does the appetite effect feel different or just stronger

LN

no gap when i switched, took the last semaglutide dose and started this a week later, i think

switched last year

back after 8 months, do i restart at 2.5 or pick up near where i left off

*2ml not 2.5

slightly off topic but plateaued at 14 weeks the same way i did on semaglutide, so i doubt its compound specific

if youre coming off semaglutide the honest answer is start low and find out, theres no table, happy to be corrected

MS

follow up the switch felt like a step down at first and then caught up around week 16

BB

whats the plateau pattern here, same as semaglutide or different

went back to semaglutide after 11 months because the cost difference mattered more than the GI, your mileage will differ

i went to 15 and came back to 10, more suppression wasnt more useful for me

GG

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

BB

10 was enough

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.

switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it

there is no clean conversion between the two, anyone giving you a ratio is guessing

im at 2.4 and thinking about 5, did anyone gain anything from that step

⚠️7

genuine question my Medutest result on a JEEP vial came in at 99.2 which is why i keep buying from them
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win

VB

On this day 8 years ago this channel logged 63 messages.

VB

Digest for the week of 2024-03-26 has been published.

PS

start low anyway

weights-monthly.csv
193 rows · not retained in the public archive
NT

the GI difference held for me right up to 15, which isnt what a couple of people here found

PS

held 10 for 2 months and lost 26kg over that stretch, slow and boring and fine

PS

anyone stopped at 10 and stayed there for months

🎉12🧪7💀2