genuine question i argued the sweet spot was nonsense and then spent 17 months at 7.5 not needing more
#tirzepatide 2024-09-10
Tuesday26 messages5 participantstimes are UTC
Highlights from this day
- seven_five_sweet — coming back to this switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it 20:42
- ferrous_ash — follow up my Janoshik result on a SSA vial came in at 96.8 which is why i keep buying from them 21:22
- mg_per_ml — genuine question im at 2 and thinking about 1, did anyone gain anything from that step 21:23
- quiet_head_qi — update on the earlier thing SURMOUNT-1 versus SURPASS-2, which one was the weight trial 21:31
15 is the top
does the GIP arm actually explain the easier nausea or is that hand waving
why does everyone talk about 7.5 and not 10
titrate slow
start low anyway
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
sorry to jump in restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists
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while im here i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from
update on the earlier thing is there a reason to titrate slower than the four week schedule
coming back to this whats the top licensed dose, 15 or does it go higher
checked the units twice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
no gap when i switched, took the last semaglutide dose and started this a week later
SURMOUNT is weight
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the GI difference held for me right up to 15, which isnt what a couple of people here found
coming back to this switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
🎉2⚠️2
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the two compounds arent interchangeable week for week even if the effect ends up similar
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follow up my Janoshik result on a SSA vial came in at 96.8 which is why i keep buying from them
💀12🎉2
genuine question im at 2 and thinking about 1, did anyone gain anything from that step
coa-a-2601.pdf
1 page · 874 KB · not retained in the public archive
there is no clean conversion between the two, anyone giving you a ratio is guessing
the trials titrated every four weeks to a target, most people here stop at whatever works
update on the earlier thing SURMOUNT-1 versus SURPASS-2, which one was the weight trial
[edited]😂4
i went to 15 and came back to 10, more suppression wasnt more useful for me
easier gi for me