did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
#tirzepatide 2024-09-13
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same plateau here
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i argued the sweet spot was nonsense and then spent 1 months at 7.5 not needing more
coming off semaglutide, is there a conversion or do i restart at 2.5
restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
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folklore probably
the sweet spot argument is really about effect per side effect, not a magic number
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
at 2.5 my appetite is gone entirely, did anyone go down rather than up
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
is SURMOUNT-OSA the sleep apnoea one
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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checked the units twice
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does the GIP arm actually explain the easier nausea or is that hand waving
start low anyway
right so no gap when i switched, took the last semaglutide dose and started this a week later
40 units of a 2 solution is a lot of volume and i check that one twice every single time
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
how did people handle the 2.5 to 5 jump
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10 was enough
changed my mind about needing 15, i was chasing a number rather than an outcome
anyone stopped at 10 and stayed there for months
went back to semaglutide after 1 months because the cost difference mattered more than the GI, ymmv
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genuine question SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, take that with a pinch of salt
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
whats the top licensed dose, 15 or does it go higher
how long before the dual thing was noticeable to you
the 40 vial in 5ml gives 2mg/ml which puts 2.5 on 10 units, nice round numbers
why does everyone talk about 7.5 and not 10
the trials titrated every four weeks to a target, most people here stop at whatever works
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does the appetite effect feel different or just stronger
genuine question does switching from semaglutide need a gap or do you just start
held 10 for 6 months and lost 10kg over that stretch, slow and boring and fine
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5 did nothing
the GI difference held for me right up to 15, which isnt what a couple of people here found
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the switch felt like a step down at first and then caught up around week 33
is the sweet spot argument about effect or about side effects
[edited]the two compounds arent interchangeable week for week even if the effect ends up similar
the sweet spot thing is survivorship, the people it worked for stayed and said so
did anyone go past 15 and was there any point to it
switched last year
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how many weeks at 7.5 before you knew it was enough