the two compounds arent interchangeable week for week even if the effect ends up similar
#tirzepatide 2024-11-23
Saturday52 messages13 participantstimes are UTC
Highlights from this day
- igf_one_ivy — while im here is the 20 vial the common one or do people use 30 17:04
- rotate_the_site — at 15 the GI came back for me, so my easier profile claim only applies below that 19:45
- peak_split — coming back to this i went to 15 and came back to 10, more suppression wasnt more useful for me 20:18
if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
start low anyway
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why does everyone talk about 7.5 and not 10
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is SURMOUNT-OSA the sleep apnoea one
does switching from semaglutide need a gap or do you just start
did anyone find the GI easier than semaglutide at an equivalent effect
12 did nothing extra over 10 for me and that still holds a year later
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15 is the top
while im here is the 20 vial the common one or do people use 30
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at 12 my appetite is gone entirely, did anyone go down rather than up
folklore probably
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€94 for a 30 vial is roughly what ive paid for the last year
held 10 for 26 months and lost 10kg over that stretch, slow and boring and fine
im at 2.5 and thinking about 12, did anyone gain anything from that step
same plateau here
7.5 gang
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the sweet spot argument is really about effect per side effect, not a magic number, someone check my working
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whats the top licensed dose, 15 or does it go higher
*VendorInvestigate not the other one
unrelated but the trials titrated every four weeks to a target, most people here stop at whatever works
i argued the sweet spot was nonsense and then spent 10 months at 7.5 not needing more
switched last year
while im here the 2.5 to 5 step was the roughest one for me and everything after was easier
the 20 vial in 5ml gives 8mg/ml which puts 0.5 on 10 units, nice round numbers
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, not advice obviously
plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific
SURMOUNT is weight
i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
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did anyone go past 15 and was there any point to it
update on the earlier thing at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
while im here went back to semaglutide after 10 months because the cost difference mattered more than the GI
the two compounds arent interchangeable week for week even if the effect ends up similar
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GIP plus GLP-1
easier gi for me
at 15 the GI came back for me, so my easier profile claim only applies below that
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
checked the units twice
restarted at 2.5 after 24 months off and the first two doses reminded me why titration exists
no gap when i switched, took the last semaglutide dose and started this a week later, ill dig out the number
10 was enough
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
5 did nothing
no clean conversion
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, i could be wrong
there is no clean conversion between the two, anyone giving you a ratio is guessing
40 units of a 10 solution is a lot of volume and i check that one twice every single time
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
titrate slow
the sweet spot thing is survivorship, the people it worked for stayed and said so
is 7.5 really the sweet spot or is that just channel folklore
coming back to this i went to 15 and came back to 10, more suppression wasnt more useful for me
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