no clean conversion
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#tirzepatide 2024-12-09
Monday42 messages8 participantstimes are UTC
Highlights from this day
how long before the dual thing was noticeable to you
does switching from semaglutide need a gap or do you just start
if youre coming off semaglutide the honest answer is start low and find out, theres no table
the 2.5 to 5 step was the roughest one for me and everything after was easier
7.5 gang
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)quick one why does everyone talk about 7.5 and not 10
changed my mind about needing 15, i was chasing a number rather than an outcome
same plateau here
coming off semaglutide, is there a conversion or do i restart at 2.5
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titrate slow
the sweet spot argument is really about effect per side effect, not a magic number
the switch felt like a step down at first and then caught up around week 4
folklore probably
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did anyone go past 15 and was there any point to it
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
update on the earlier thing how did people handle the 2.5 to 5 jump
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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checked the units twice
restarted at 2.5 after 1 months off and the first two doses reminded me why titration exists
switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
Recon calculator: 2mg in 3ml = 2mg/ml.
SURMOUNT is weight
im at 0.25 and thinking about 5, did anyone gain anything from that step
did going from 1 semaglutide to 5 of this feel like a step down for anyone
[edited]there is no clean conversion between the two, anyone giving you a ratio is guessing, ymmv
whats the plateau pattern here, same as semaglutide or different
start low anyway
is the 40 vial the common one or do people use 20
anyone tracked whether the GI difference held at the top doses
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
ok so does the GIP arm actually explain the easier nausea or is that hand waving
is 7.5 really the sweet spot or is that just channel folklore
i sat at 7.5 for 4 months and never needed more, which is where the folklore comes from
went back to semaglutide after 2 months because the cost difference mattered more than the GI
easier gi for me
15 is the top
no gap when i switched, took the last semaglutide dose and started this a week later, i think
my PeptideMeter result on a HJ vial came in at 96.8 which is why i keep buying from them
did anybody switch back to semaglutide after trying this
is there a reason to titrate slower than the four week schedule