GIP plus GLP-1
[edited]Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.
GIP plus GLP-1
[edited]#tirzepatide 2024-12-08
Sunday47 messages11 participantstimes are UTC
Highlights from this day
- lead_time_lars — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 12 did nothing extra over 10 for me and that still holds a year later 19:01
- pinch_not_stretch — 12 did nothing extra over 10 for me and that still holds a year later 19:36
- slow.taper — the two compounds arent interchangeable week for week even if the effect ends up similar 22:26
- thirty_min_wait — £120 for a 40 vial is roughly what ive paid for the last year 23:02
- thirty_min_wait — if youre coming off semaglutide the honest answer is start low and find out, theres no table 23:27
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
12 did nothing extra over 10 for me and that still holds a year later
❤️16🙏12
the GI difference held for me right up to 15, which isnt what a couple of people here found
genuine question at 15 the GI came back for me, so my easier profile claim only applies below that, we shall see
the switch felt like a step down at first and then caught up around week 10
did going from 15 semaglutide to 5 of this feel like a step down for anyone
no gap when i switched, took the last semaglutide dose and started this a week later
Recon calculator: 30mg in 1.5ml = 4mg/ml.
12 did nothing extra over 10 for me and that still holds a year later
💀14
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
same plateau here
the 2.5 to 5 step was the roughest one for me and everything after was easier, happy to be corrected
[edited]does the GIP arm actually explain the easier nausea or is that hand waving
20:01marrow.mod pinned a message
went back to semaglutide after 14 months because the cost difference mattered more than the GI
at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
quick one is 7.5 really the sweet spot or is that just channel folklore
plateaued at 12 weeks the same way i did on semaglutide, so i doubt its compound specific, from memory
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists
quick one 5 was where i first noticed it properly, 2.5 did almost nothing for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, still working it out
the 5 vial in 1ml gives 4mg/ml which puts 7.5 on 12 units, nice round numbers
back after 7 months, do i restart at 2.5 or pick up near where i left off
titrate slow
there is no clean conversion between the two, anyone giving you a ratio is guessing
how did people handle the 2.5 to 5 jump
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
*2ml not 2.5
easier gi for me
15 is the top
does switching from semaglutide need a gap or do you just start
did anybody switch back to semaglutide after trying this
SURMOUNT is weight
the sweet spot thing is survivorship, the people it worked for stayed and said so
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from, from memory
checked the units twice
im at 2.4 and thinking about 1, did anyone gain anything from that step
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
10 was enough
quick one switched from 7.5 semaglutide and started at 2.5, took the slow route, never regretted it, still working it out
the two compounds arent interchangeable week for week even if the effect ends up similar
👀16🧊17😂15
7.5 gang
anyone tracked whether the GI difference held at the top doses
anyone stopped at 10 and stayed there for months
£120 for a 40 vial is roughly what ive paid for the last year
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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