how long before the dual thing was noticeable to you
#tirzepatide 2025-01-06
Monday36 messages7 participantstimes are UTC
Highlights from this day
- seven_five_sweet — £240 for a 10 vial is roughly what ive paid for the last year 20:36
- HPLC_Hank — coming back to this did going from 5 semaglutide to 5 of this feel like a step down for anyone 21:28
- HPLC_Hank — at 0.5 my appetite is gone entirely, did anyone go down rather than up 21:40
- VialBot — Assay note: CPC lot C-4402 reported at 96.8% of label content. 21:55
- wrong_network — unrelated but there is no clean conversion between the two, anyone giving you a ratio is guessing, ill dig out the number 22:47
same plateau here
£240 for a 10 vial is roughly what ive paid for the last year
👀1🔥1🤝12
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
if youre coming off semaglutide the honest answer is start low and find out, theres no table
plateaued at 25 weeks the same way i did on semaglutide, so i doubt its compound specific
if youre coming off semaglutide the honest answer is start low and find out, theres no table
i argued the sweet spot was nonsense and then spent 15 months at 7.5 not needing more
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
🙏3
does the appetite effect feel different or just stronger
15 is the top
is the sweet spot argument about effect or about side effects
right so at 15 the GI came back for me, so my easier profile claim only applies below that
12 did nothing extra over 10 for me and that still holds a year later
whats the top licensed dose, 15 or does it go higher
coming back to this did going from 5 semaglutide to 5 of this feel like a step down for anyone
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the 15 vial in 2.5ml gives 8mg/ml which puts 10 on 5 units, nice round numbers
anyone tracked whether the GI difference held at the top doses
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
[edited]at 0.5 my appetite is gone entirely, did anyone go down rather than up
⚠️16🧊17
start low anyway
how many weeks at 7.5 before you knew it was enough
checked the units twice
Assay note: CPC lot C-4402 reported at 96.8% of label content.
GIP plus GLP-1
5 did nothing
held 10 for 23 months and lost 21kg over that stretch, slow and boring and fine
7.5 gang
did anybody switch back to semaglutide after trying this
i went to 15 and came back to 10, more suppression wasnt more useful for me
easier gi for me
switched last year
no clean conversion
the sweet spot thing is survivorship, the people it worked for stayed and said so
unrelated but there is no clean conversion between the two, anyone giving you a ratio is guessing, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
💀2🧪12🧊1
SURMOUNT is weight