the trials titrated every four weeks to a target, most people here stop at whatever works
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is SURMOUNT-OSA the sleep apnoea one
held 10 for 7 months and lost 29kg over that stretch, slow and boring and fine, take that with a pinch of salt
i argued the sweet spot was nonsense and then spent 9 months at 7.5 not needing more
whats the plateau pattern here, same as semaglutide or different
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the two compounds arent interchangeable week for week even if the effect ends up similar
7.5 gang
ok so is 7.5 really the sweet spot or is that just channel folklore
how did people handle the 2.5 to 5 jump
went back to semaglutide after 7 months because the cost difference mattered more than the GI
is the sweet spot argument about effect or about side effects
im at 15 and thinking about 12, did anyone gain anything from that step
checked the units twice
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the switch felt like a step down at first and then caught up around week 19
if youre coming off semaglutide the honest answer is start low and find out, theres no table
changed my mind about needing 15, i was chasing a number rather than an outcome
*Medutest not the other one
how many weeks at 7.5 before you knew it was enough
the GI difference held for me right up to 15, which isnt what a couple of people here found, anyway
the sweet spot argument is really about effect per side effect, not a magic number
i went to 15 and came back to 10, more suppression wasnt more useful for me
12 did nothing extra over 10 for me and that still holds a year later
is the 30 vial the common one or do people use 2
[edited]GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it