switched last year
#tirzepatide 2025-02-03
Monday43 messages11 participantstimes are UTC
Highlights from this day
for the archive coming off semaglutide, is there a conversion or do i restart at 2.5
is SURMOUNT-OSA the sleep apnoea one
while im here there is no clean conversion between the two, anyone giving you a ratio is guessing
is 7.5 really the sweet spot or is that just channel folklore
Purity check: no report on file for lot SG-1177. Nothing logged either way.
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how many weeks at 7.5 before you knew it was enough
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im at 12 and thinking about 1.7, did anyone gain anything from that step
15 is the top
if youre coming off semaglutide the honest answer is start low and find out, theres no table, not advice obviously
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
7.5 gang
how long before the dual thing was noticeable to you
at 10 my appetite is gone entirely, did anyone go down rather than up
i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from
restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists
same plateau here
plateaued at 30 weeks the same way i did on semaglutide, so i doubt its compound specific
at 15 the GI came back for me, so my easier profile claim only applies below that, happy to be corrected
checked the units twice
held 10 for 8 months and lost 31kg over that stretch, slow and boring and fine
medutest-report-kp-0925.pdf
3 pages · 362 KB · not retained in the public archive
the 40 vial in 5ml gives 5mg/ml which puts 1.7 on 15 units, nice round numbers
sorry to jump in back after 2 months, do i restart at 2.5 or pick up near where i left off
why does everyone talk about 7.5 and not 10
coming back to this whats the top licensed dose, 15 or does it go higher
does the GIP arm actually explain the easier nausea or is that hand waving
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at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
the trials titrated every four weeks to a target, most people here stop at whatever works
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
5 did nothing
the two compounds arent interchangeable week for week even if the effect ends up similar
the sweet spot thing is survivorship, the people it worked for stayed and said so
did going from 12 semaglutide to 5 of this feel like a step down for anyone
the sweet spot thing is survivorship, the people it worked for stayed and said so
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SURMOUNT is weight
anyone stopped at 10 and stayed there for months
40 units of a 5 solution is a lot of volume and i check that one twice every single time
GIP plus GLP-1
no clean conversion
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, for what its worth
did anyone go past 15 and was there any point to it
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)£240 for a 15 vial is roughly what ive paid for the last year, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the 2.5 to 5 step was the roughest one for me and everything after was easier, n of 1 obviously
12 did nothing extra over 10 for me and that still holds a year later
unrelated but did anybody switch back to semaglutide after trying this