did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
#tirzepatide 2025-04-10
Thursday39 messages9 participantstimes are UTC
Highlights from this day
- point_two_five — i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from 10:52
- factory_direct_fi — switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it 14:20
- slow.taper — while im here changed my mind about needing 15, i was chasing a number rather than an outcome 15:45
how did people handle the 2.5 to 5 jump
coming off semaglutide, is there a conversion or do i restart at 2.5
12 did nothing extra over 10 for me and that still holds a year later
*that should say weekly
plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
i went to 15 and came back to 10, more suppression wasnt more useful for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table, thats just me
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is there a reason to titrate slower than the four week schedule
Verification log updated: JEEP — evidence added, status unchanged.
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
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40 units of a 4 solution is a lot of volume and i check that one twice every single time
no clean conversion
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
checked the units twice
anyone tracked whether the GI difference held at the top doses
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is the sweet spot argument about effect or about side effects
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the sweet spot argument is really about effect per side effect, not a magic number
switched last year
i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
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im at 1 and thinking about 12, did anyone gain anything from that step
is the 15 vial the common one or do people use 2
the 5 vial in 5ml gives 4mg/ml which puts 2 on 30 units, nice round numbers, not advice obviously
sorry to jump in SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 15 the GI came back for me, so my easier profile claim only applies below that
follow up does the appetite effect feel different or just stronger
GIP plus GLP-1
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same plateau here
SURMOUNT is weight
my Janoshik result on a FGP vial came in at 97.4 which is why i keep buying from them
there is no clean conversion between the two, anyone giving you a ratio is guessing
follow up the trials titrated every four weeks to a target, most people here stop at whatever works
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
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5 did nothing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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is SURMOUNT-OSA the sleep apnoea one
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while im here changed my mind about needing 15, i was chasing a number rather than an outcome
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