does switching from semaglutide need a gap or do you just start
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#tirzepatide 2025-04-12
Saturday54 messages12 participantstimes are UTC
Highlights from this day
- forty_units — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 19:36
- ferrous_ash — the 5 vial in 3ml gives 4mg/ml which puts 15 on 30 units, nice round numbers, ymmv 19:41
- gall_bladder_gav — at 15 the GI came back for me, so my easier profile claim only applies below that 20:56
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
$185 for a 2 vial is roughly what ive paid for the last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
does the appetite effect feel different or just stronger
whats the plateau pattern here, same as semaglutide or different
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is SURMOUNT-OSA the sleep apnoea one
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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the 5 vial in 3ml gives 4mg/ml which puts 15 on 30 units, nice round numbers, ymmv
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the trials titrated every four weeks to a target, most people here stop at whatever works
anyone got a 2 recon they like for the 40 vials
the two compounds arent interchangeable week for week even if the effect ends up similar
right so no gap when i switched, took the last semaglutide dose and started this a week later, ymmv
my Janoshik result on a WXT vial came in at 98.1 which is why i keep buying from them
[edited]the sweet spot argument is really about effect per side effect, not a magic number
changed my mind about needing 15, i was chasing a number rather than an outcome
titrate slow
the switch felt like a step down at first and then caught up around week 29
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Digest for the week of 2025-01-06 has been published.
how many weeks at 7.5 before you knew it was enough
15 is the top
same plateau here
GIP plus GLP-1
7.5 gang
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there is no clean conversion between the two, anyone giving you a ratio is guessing
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5 was where i first noticed it properly, 2.5 did almost nothing for me
the two compounds arent interchangeable week for week even if the effect ends up similar
anyone stopped at 10 and stayed there for months
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
Archive lookup: ferrous_ash first appears in this channel on 2024-12-26.
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i could be wrong
coming back to this 40 units of a 4 solution is a lot of volume and i check that one twice every single time
SURMOUNT is weight
at 15 the GI came back for me, so my easier profile claim only applies below that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held 10 for 18 months and lost 17kg over that stretch, slow and boring and fine, ask me again in a month
im at 0.25 and thinking about 2, did anyone gain anything from that step
start low anyway
the 2.5 to 5 step was the roughest one for me and everything after was easier
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at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
whats the top licensed dose, 15 or does it go higher
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i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
how long before the dual thing was noticeable to you
peptidemeter-summary-f-1330.pdf
2 pages · 220 KB · not retained in the public archive
easier gi for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
i went to 15 and came back to 10, more suppression wasnt more useful for me
no clean conversion
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
is 7.5 really the sweet spot or is that just channel folklore
easier gi for me, someone check my working
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12 did nothing extra over 10 for me and that still holds a year later
10 was enough