#tirzepatide 2025-05-02

titrate slow

same plateau here

for the archive how many weeks at 7.5 before you knew it was enough

coming off semaglutide, is there a conversion or do i restart at 2.5

plateaued at 15 weeks the same way i did on semaglutide, so i doubt its compound specific

the sweet spot argument is really about effect per side effect, not a magic number

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

the trials titrated every four weeks to a target, most people here stop at whatever works

is there a reason to titrate slower than the four week schedule

Digest for the week of 2024-11-14 has been published.

7.5 gang

the switch felt like a step down at first and then caught up around week 8

held 10 for 15 months and lost 4kg over that stretch, slow and boring and fine
the trials titrated every four weeks to a target, most people here stop at whatever works

while im here there is no clean conversion between the two, anyone giving you a ratio is guessing

did anyone find the GI easier than semaglutide at an equivalent effect

checked the units twice

changed my mind about needing 15, i was chasing a number rather than an outcome

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

Digest for the week of 2025-01-25 has been published.

the two compounds arent interchangeable week for week even if the effect ends up similar

for the archive i argued the sweet spot was nonsense and then spent 1 months at 7.5 not needing more

SURMOUNT is weight

went back to semaglutide after 2 months because the cost difference mattered more than the GI

the GI difference held for me right up to 15, which isnt what a couple of people here found

Digest for the week of 2024-11-01 has been published.

GIP plus GLP-1

no gap when i switched, took the last semaglutide dose and started this a week later

€38 for a 40 vial is roughly what ive paid for the last year

does the appetite effect feel different or just stronger

how long before the dual thing was noticeable to you
the 2.5 to 5 step was the roughest one for me and everything after was easier

update on the earlier thing is 7.5 really the sweet spot or is that just channel folklore

i log everything and my appetite curve looks flatter across the week than my semaglutide log did

did going from 1.7 semaglutide to 5 of this feel like a step down for anyone

did anybody switch back to semaglutide after trying this

i went to 15 and came back to 10, more suppression wasnt more useful for me

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

no clean conversion

the 10 vial in 1.5ml gives 4mg/ml which puts 0.5 on 12 units, nice round numbers

5 did nothing

10 was enough

easier gi for me

the sweet spot thing is survivorship, the people it worked for stayed and said so