start low anyway
🙏3✅1🔥8
#tirzepatide 2025-05-03
Saturday36 messages8 participantstimes are UTC
Highlights from this day
- alt_ast_ali — is 7.5 really the sweet spot or is that just channel folklore 19:27
- alt_ast_ali — the trials titrated every four weeks to a target, most people here stop at whatever works 20:01
- triple_ag_tom — plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific 20:19
titrate slow
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)SURMOUNT is weight
checked the units twice
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the 40 vial in 2ml gives 2mg/ml which puts 2.5 on 25 units, nice round numbers
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
👀3
GIP plus GLP-1
i went to 15 and came back to 10, more suppression wasnt more useful for me
folklore probably
🤝1📈10🧊3
5 did nothing
😂6👍16
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, ask me again in a month
sorry to jump in anyone tracked whether the GI difference held at the top doses
the two compounds arent interchangeable week for week even if the effect ends up similar, from memory
switched last year
no clean conversion
follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
7.5 gang
easier gi for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
is SURMOUNT-OSA the sleep apnoea one
same plateau here
15 is the top
🎉1💀3
i argued the sweet spot was nonsense and then spent 17 months at 7.5 not needing more
is 7.5 really the sweet spot or is that just channel folklore
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
back after 13 months, do i restart at 2.5 or pick up near where i left off
held 10 for 5 months and lost 44kg over that stretch, slow and boring and fine
sharps_bin_sidSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix…
changed my mind about needing 15, i was chasing a number rather than an outcome
🧊4😂5
the trials titrated every four weeks to a target, most people here stop at whatever works
[edited]⚠️17💀12
$120 for a 10 vial is roughly what ive paid for the last year
40 units of a 2 solution is a lot of volume and i check that one twice every single time
plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
⚠️1🔥13🧊3
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
📉1
if youre coming off semaglutide the honest answer is start low and find out, theres no table
anyone got a 2.5 recon they like for the 40 vials
at 2.4 my appetite is gone entirely, did anyone go down rather than up