vialroom

#tirzepatide 2025-06-14

Saturday23 messages7 participantstimes are UTC
Highlights from this day
  • surpass_two — sorry to jump in does the GIP arm actually explain the easier nausea or is that hand waving 12:08
  • bengaluru_bac — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 12:11
  • bengaluru_bac — is the sweet spot argument about effect or about side effects 12:15
  • VialBot — Assay note: CPC lot KP-0925 reported at 98.6% of label content. 12:57
  • first_and_last_four — im at 15 and thinking about 5, did anyone gain anything from that step 13:15
SD

genuine question licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win

unrelated but does switching from semaglutide need a gap or do you just start

switched last year

ST

sorry to jump in does the GIP arm actually explain the easier nausea or is that hand waving

💀818
BB

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
🤝16

no gap when i switched, took the last semaglutide dose and started this a week later

did anyone find the GI easier than semaglutide at an equivalent effect

VB

Assay note: CPC lot KP-0925 reported at 98.6% of label content.

😂2📉2
BB

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

SD

changed my mind about needing 15, i was chasing a number rather than an outcome

CO

if youre coming off semaglutide the honest answer is start low and find out, theres no table, i think

anyone stopped at 10 and stayed there for months

CO

coming off semaglutide, is there a conversion or do i restart at 2.5

CO

restarted at 2.5 after 18 months off and the first two doses reminded me why titration exists, thats just me

the 2.5 to 5 step was the roughest one for me and everything after was easier, i think

*VendorInvestigate not the other one