did anyone go past 15 and was there any point to it
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#tirzepatide 2025-06-15
Sunday56 messages12 participantstimes are UTC
Highlights from this day
- egfr_ed — did anyone go past 15 and was there any point to it 21:28
- egfr_ed — does the GIP arm actually explain the easier nausea or is that hand waving 21:37
- u100_pat — if youre coming off semaglutide the honest answer is start low and find out, theres no table 21:56
- coffee_only — sorry to jump in there is no clean conversion between the two, anyone giving you a ratio is guessing 22:03
- egfr_ed — im at 0.5 and thinking about 12, did anyone gain anything from that step 23:00
i argued the sweet spot was nonsense and then spent 8 months at 7.5 not needing more
is SURMOUNT-OSA the sleep apnoea one
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the sweet spot argument is really about effect per side effect, not a magic number
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
does the GIP arm actually explain the easier nausea or is that hand waving
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same plateau here
does the appetite effect feel different or just stronger
update on the earlier thing SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the 2.5 to 5 step was the roughest one for me and everything after was easier
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titrate slow
is the 30 vial the common one or do people use 20
how did people handle the 2.5 to 5 jump
7.5 gang
whats the plateau pattern here, same as semaglutide or different
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
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switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
GIP plus GLP-1
coming off semaglutide, is there a conversion or do i restart at 2.5
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)sorry to jump in there is no clean conversion between the two, anyone giving you a ratio is guessing
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ok so dual agonist, GIP as well as GLP-1, thats the whole difference in one line
15 is the top
how long before the dual thing was noticeable to you
went back to semaglutide after 15 months because the cost difference mattered more than the GI, ill dig out the number
my VendorInvestigate result on a ERP vial came in at 99.4 which is why i keep buying from them
plateaued at 33 weeks the same way i did on semaglutide, so i doubt its compound specific, thats just me
follow up did anybody switch back to semaglutide after trying this
the sweet spot thing is survivorship, the people it worked for stayed and said so
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easier gi for me
did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
switched last year
Reminder for dexa_or_bia: dose day is today. Set 4 days ago.
folklore probably
checked the units twice
slightly off topic but no gap when i switched, took the last semaglutide dose and started this a week later
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
no clean conversion
SURMOUNT is weight
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
5 did nothing
im at 0.5 and thinking about 12, did anyone gain anything from that step
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anyone stopped at 10 and stayed there for months
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
follow up does switching from semaglutide need a gap or do you just start
right so i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
40 units of a 2 solution is a lot of volume and i check that one twice every single time
the 2 vial in 5ml gives 4mg/ml which puts 12 on 30 units, nice round numbers
the switch felt like a step down at first and then caught up around week 17
the trials titrated every four weeks to a target, most people here stop at whatever works
held 10 for 2 months and lost 18kg over that stretch, slow and boring and fine
€185 for a 2 vial is roughly what ive paid for the last year
5 was where i first noticed it properly, 2.5 did almost nothing for me