did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
#tirzepatide 2025-06-25
Wednesday22 messages7 participantstimes are UTC
Highlights from this day
restarted at 2.5 after 6 months off and the first two doses reminded me why titration exists
Digest for the week of 2025-04-25 has been published.
5 did nothing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)genuine question 12 did nothing extra over 10 for me and that still holds a year later
ok so SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
start low anyway
back after 21 months, do i restart at 2.5 or pick up near where i left off
coming back to this the 2.5 to 5 step was the roughest one for me and everything after was easier
held 10 for 2 months and lost 15kg over that stretch, slow and boring and fine
plateaued at 18 weeks the same way i did on semaglutide, so i doubt its compound specific
how long before the dual thing was noticeable to you
15 is the top
same plateau here
the 5 vial in 3ml gives 2.5mg/ml which puts 0.5 on 15 units, nice round numbers
checked the units twice
does the appetite effect feel different or just stronger
⚠️7✅12🙏2
folklore probably
whats the plateau pattern here, same as semaglutide or different
🧪15✅1
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
10 was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact