how did people handle the 2.5 to 5 jump
#tirzepatide 2025-07-02
Wednesday39 messages6 participantstimes are UTC
Highlights from this day
- nordic_price_nils — did anyone go past 15 and was there any point to it 20:36
- electrolyte_eli — does switching from semaglutide need a gap or do you just start 20:41
- electrolyte_eli — the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv 21:13
- nordic_price_nils — no gap when i switched, took the last semaglutide dose and started this a week later 21:28
went back to semaglutide after 17 months because the cost difference mattered more than the GI
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
did anyone find the GI easier than semaglutide at an equivalent effect
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the two compounds arent interchangeable week for week even if the effect ends up similar
for the archive at 15 the GI came back for me, so my easier profile claim only applies below that, ymmv
5 was where i first noticed it properly, 2.5 did almost nothing for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
unrelated but does the appetite effect feel different or just stronger
whats the plateau pattern here, same as semaglutide or different
is the 5 vial the common one or do people use 20
back after 19 months, do i restart at 2.5 or pick up near where i left off
restarted at 2.5 after 21 months off and the first two doses reminded me why titration exists
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
i went to 15 and came back to 10, more suppression wasnt more useful for me
[edited]i log everything and my appetite curve looks flatter across the week than my semaglutide log did
GIP plus GLP-1
💀1🤝1📉1
easier gi for me
📈12📉11
why does everyone talk about 7.5 and not 10
is 7.5 really the sweet spot or is that just channel folklore
no clean conversion
[edited]im at 2 and thinking about 1.7, did anyone gain anything from that step
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
⚠️2
10 was enough
changed my mind about needing 15, i was chasing a number rather than an outcome
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the trials titrated every four weeks to a target, most people here stop at whatever works
does the GIP arm actually explain the easier nausea or is that hand waving
the 30 vial in 2ml gives 2mg/ml which puts 12 on 30 units, nice round numbers
there is no clean conversion between the two, anyone giving you a ratio is guessing
did anyone go past 15 and was there any point to it
❤️10🧊10
15 is the top
does switching from semaglutide need a gap or do you just start
🎉18😂8✅15
the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv
🎉10
the 2.5 to 5 step was the roughest one for me and everything after was easier
5 did nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
anyone got a 4 recon they like for the 2 vials
no gap when i switched, took the last semaglutide dose and started this a week later
🔥10💀3
plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific