is there a reason to titrate slower than the four week schedule
#tirzepatide 2025-07-27
Sunday53 messages12 participantstimes are UTC
Highlights from this day
- transit_degrade — no gap when i switched, took the last semaglutide dose and started this a week later 15:19
- protein_floor — if youre coming off semaglutide the honest answer is start low and find out, theres no table 18:42
- no_chargeback — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 18:51
is the 10 vial the common one or do people use 30
*Medutest not the other one
at 15 the GI came back for me, so my easier profile claim only applies below that
no gap when i switched, took the last semaglutide dose and started this a week later
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40 units of a 2 solution is a lot of volume and i check that one twice every single time
start low anyway
switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it
Channel stats, last 30 days: 17 messages from 16 members.
i sat at 7.5 for 11 months and never needed more, which is where the folklore comes from
did anyone find the GI easier than semaglutide at an equivalent effect
the two compounds arent interchangeable week for week even if the effect ends up similar
5 did nothing
5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
checked the units twice
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unrelated but at 1 my appetite went completely and i dropped back a step, eating nothing isnt a win
the trials titrated every four weeks to a target, most people here stop at whatever works
SURMOUNT is weight
right so i went to 15 and came back to 10, more suppression wasnt more useful for me
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switched last year
how many weeks at 7.5 before you knew it was enough
easier gi for me
there is no clean conversion between the two, anyone giving you a ratio is guessing
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
7.5 gang
$72 for a 30 vial is roughly what ive paid for the last year
no clean conversion
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15 is the top
GIP plus GLP-1
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folklore probably
same plateau here
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coming back to this dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
[edited]restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists
10 was enough
if youre coming off semaglutide the honest answer is start low and find out, theres no table
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i log everything and my appetite curve looks flatter across the week than my semaglutide log did
18:47chlorhex pinned a message
went back to semaglutide after 12 months because the cost difference mattered more than the GI
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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changed my mind about needing 15, i was chasing a number rather than an outcome, happy to be corrected
18:53chlorhex pinned a message to this channel
did anybody switch back to semaglutide after trying this
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the trials titrated every four weeks to a target, most people here stop at whatever works
Testing queue: 8 submissions open, 26 awaiting dispatch.
held 10 for 3 months and lost 11kg over that stretch, slow and boring and fine
follow up 15 is the top, from memory
plateaued at 13 weeks the same way i did on semaglutide, so i doubt its compound specific
*Janoshik not the other one
the 2.5 to 5 step was the roughest one for me and everything after was easier
changed my mind about needing 15, i was chasing a number rather than an outcome